MW 451 Da, Purity >97%. Selective inhibitor of cyclic nucleotide-gated (CNG) channels. Blocks rod-type CNGA1, olfactory-type CNGA2 and cone-type CNGA3, at micromolar concentrations. Optical isomer of diltiazem (ab120260). Protects against myocardial dysfunction in vitro.
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- Cell death & disease 13:472022Redefining the role of Ca-permeable channels in photoreceptor degeneration using diltiazem.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSoumyaparna Das,Valerie Popp,Michael Power,Kathrin Groeneveld,Jie Yan,Christian Melle,Luke Rogerson,Marlly Achury,Frank Schwede,Torsten Strasser,Thomas Euler,François Paquet-Durand,Vasilica NachePubMed 35013127
- eLife 6:2017cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool.Applications:Unspecified applicationReactive species:Unspecified reactive speciesVladimir Camarena et. al.PubMed 29239726
- PloS one 12:e01724912017Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLea Weber et. al.PubMed 28273117
- Frontiers in physiology 7:3392016Olfactory Receptors Modulate Physiological Processes in Human Airway Smooth Muscle Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBenjamin Kalbe et. al.PubMed 27540365
- The Journal of neuroscience : the official journal of the Society for Neuroscience 34:3268-782014Transduction for pheromones in the main olfactory epithelium is mediated by the Ca2+ -activated channel TRPM5.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFabián López,Ricardo Delgado,Roberto López,Juan Bacigalupo,Diego RestrepoPubMed 24573286
Key facts
- CAS number
- 42399-54-2
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 451 Da
- Molecular formula
- C22H27ClN2O4S
- PubChem identifier
- 198106
- Nature
- Synthetic
Recommended products
MW 451 Da, Purity >97%. Selective inhibitor of cyclic nucleotide-gated (CNG) channels. Blocks rod-type CNGA1, olfactory-type CNGA2 and cone-type CNGA3, at micromolar concentrations. Optical isomer of diltiazem (ab120260). Protects against myocardial dysfunction in vitro.
Key facts
- CAS number
- 42399-54-2
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 451 Da
- Molecular formula
- C22H27ClN2O4S
- PubChem identifier
- 198106
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
- Ent-diltiazem hydrochloride
- Biological description
Selective inhibitor of cyclic nucleotide-gated (CNG) channels. Blocks rod-type CNGA1, olfactory-type CNGA2 and cone-type CNGA3, at micromolar concentrations. Optical isomer of diltiazem (ab120260). Protects against myocardial dysfunction in vitro.
- Canonical SMILES
- CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
- Isomeric SMILES
- CC(=O)O[C@H]1[C@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
- InChI
- InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m0./s1
- InChIKey
- HDRXZJPWHTXQRI-JUDYQFGCSA-N
- IUPAC name
- [(2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
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1 product image
Chemical Structure - L-cis-Diltiazem, cyclic nucleotide-gated channel blocker (ab120532)
2D chemical structure image of ab120532, L-cis-Diltiazem, cyclic nucleotide-gated channel blocker
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