L-DOPA, Dopamine (ab120565) precursor
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(9 Publications)
MW 197.19 Da, Purity >99%. Dopamine (ab120565) precursor. Blood-brain barrier permeable. Increases dopamine levels in Parkinson's disease models to display anti-Parkinson's disease properties.
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AML 1, AML1 EVI 1, AML1 EVI 1 fusion protein, AMLCR 1, Acute myeloid leukemia 1, Acute myeloid leukemia 1 protein, Aml1 oncogene, BLM_HUMAN, BS, Bloom syndrome, Bloom syndrome RecQ helicase like, Bloom syndrome protein, CA 1, CA 12, CA 13, CA 14, CA 2, CA IV, CA VA, CA VB, CA-I, CA-II, CA-VI, CA-XII, CA-XIII, CA-XIV, CA13 carbonic anhydrase XIII, CA4, CA5, CA5B, CA6, CAB, CAC, CAH12_HUMAN, CAH13_HUMAN, CAH14_HUMAN, CAH1_HUMAN, CAH2_HUMAN, CAH4_HUMAN, CAH5B_HUMAN, CAH6_HUMAN, CAV, CBF b, CBF-alpha-2, CBF-beta, CBFA 2, Car 1, Car 2, Car4, Carbonate dehydratase I, Carbonate dehydratase II, Carbonate dehydratase IV, Carbonate dehydratase VA, Carbonate dehydratase VB, Carbonate dehydratase VI, Carbonate dehydratase XII, Carbonate dehydratase XIII, Carbonate dehydratase XIV, Carbonic anhydrase 1, Carbonic anhydrase 12, Carbonic anhydrase 13, Carbonic anhydrase 14, Carbonic anhydrase 2, Carbonic anhydrase 4, Carbonic anhydrase 5B, Carbonic anhydrase 5B, mitochondrial, Carbonic anhydrase 6, Carbonic anhydrase A, Carbonic anhydrase B, Carbonic anhydrase B, formerly, Carbonic anhydrase C, Carbonic anhydrase C, formerly, Carbonic anhydrase I, Carbonic anhydrase II, Carbonic anhydrase VA, Carbonic anhydrase VA mitochondrial, Carbonic anhydrase VB, Carbonic anhydrase VB, mitochondrial, Carbonic anhydrase VI, Carbonic anhydrase XII, Carbonic anhydrase XIII, Carbonic anhydrase XIV, Carbonic dehydratase, Carbonic dehydratase IV, Core binding factor alpha 2 subunit, Core binding factor beta subunit, Core binding factor runt domain alpha subunit 2, Core-binding factor subunit alpha-2, Core-binding factor subunit beta, Core-binding factor, beta subunit (CBFB), transcript variant 2, DNA directed DNA polymerase beta, DNA helicase, DNA helicase RecQ like type 2, DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit, DNA polymerase eta, DNA polymerase iota, DPOLB_HUMAN, EC 4.2.1.1, EC=4.2.1.1, ECK0125, Epididymis secretory protein Li 282, Eta 2, FLJ16395, FLJ20151, FLJ21978, GUSTIN, HEL-76, HEL-S-282, HGNC, HSMPP8, HsT18816, JW0122, M-phase phosphoprotein 8, M-phase phosphoprotein, mpp, M-phase phosphoprotein, mpp8, MGC125976, MGC126616, MGC131618, MGC131620, MGC21256, MPHOSPH8, MPP8_HUMAN, OTTHUMP00000108696, OTTHUMP00000108697, OTTHUMP00000108699, OTTHUMP00000108700, OTTHUMP00000108702, Oncogene AML-1, PEA 2, PEA2-alpha B, PEA2-beta, PEBB_HUMAN, PEBP 2B, PEBP2-alpha B, PEBP2-beta, PEBP2A2, PEBP2aB, POLH_HUMAN, POLI_HUMAN, Pol B, Pol beta, Polymerase (DNA directed) beta, Polymerase (DNA directed) iota, Polyomavirus enhancer-binding protein 2 alpha B subunit, Polyomavirus enhancer-binding protein 2 beta subunit, RAD 30B, RAD30, RAD30 homolog A, RAD30 homolog B, RAD30, S. cerevisiae, homolog of, RAD30A, RAD3OB, RECQ 2, RECQ like, RECQL 2, RECQL 3, RP11-523H24.1, RP17, RUNX1_HUMAN, RecQ protein-like 3, RecQ-like type 2, Retinitis pigmentosa 17 (autosomal dominant), Run1, Runt-related transcription factor 1, SL3 3 enhancer factor 1 beta subunit, SL3-3 enhancer factor 1 alpha B subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor alpha B subunit, SL3/AKV core-binding factor beta subunit, Salivary carbonic anhydrase, Secreted carbonic anhydrase, T18816, Tumor antigen HOM-RCC-3.1.3, Twa3, Two hybrid-associated protein 3 with RanBPM, UNQ690/PRO1335, XP V, Xeroderma pigmentosum variant type protein, alpha subunit core binding factor, carbonic anhydrase 5A mitochondrial, carbonic anhydrase V mitochondrial, carbonic anhydrase VA mitochondrial1, carbonic anhydrase VI nirs variant 1, carbonic anhydrase VI nirs variant 3, epididymis luminal protein 76, mitochondrial, polymerase DNA directed eta, type 2, yadF
- Chemical Structure
Lab
Chemical Structure - L-DOPA, Dopamine (ab120565) precursor (AB120573)
2D chemical structure image of ab120573, L-DOPA, Dopamine (ab120565) precursor
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
DNA polymerase beta must maintain genome integrity and stability. It does not operate in isolation but as part of a protein complex involved in recognizing and repairing erroneous DNA base pairing. DNA polymerase iota is also a member of the DNA polymerase family operating differently by introducing errors selectively which is sometimes beneficial in bypassing DNA lesions. The carbonic anhydrase family including CA2 CA1 and other forms plays a role in catalyzing the reversible hydration of carbon dioxide essential for maintaining acid-base balance. Each member of this family such as CA4 and CA12 has distinct tissue distributions and specific roles.
Pathways
DNA polymerase beta contributes significantly to the base excision repair (BER) pathway a critical pathway for repairing minor DNA damage. The BER pathway involves several proteins including PARP (poly ADP-ribose polymerase) which detects DNA strand breakage and recruits other repair enzymes including POLB. The pathway regulates DNA stability within both normal physiological processes and in response to chemical damage. In contrast the carbonic anhydrases are involved in bicarbonate transport pathways important for processes like respiration and renal acid-base regulation.
Publications (9)
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International journal of molecular sciences 26: PubMed40076918
2025
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International journal of molecular sciences 24: PubMed37834195
2023
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The Journal of physiology 599:4455-4476 PubMed34411301
2021
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Genes & development 34:37-52 PubMed31831628
2019
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Cell 174:481-496.e19 PubMed30007419
2018
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Frontiers in pharmacology 8:700 PubMed29046640
2017
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Scientific reports 7:9181 PubMed28835637
2017
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Scientific reports 5:16823 PubMed26592948
2015
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Disease models & mechanisms 8:57-63 PubMed25398851
2014
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