JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120049

L-Glutamate, excitatory neurotransmitter

Be the first to review this product! Submit a review

|

(10 Publications)

MW 147.13 Da, Purity >99%. Major excitatory neurotransmitter. Acts at glutamate receptors. Active in vivo.
2 Images
Immunocytochemistry/ Immunofluorescence - L-Glutamate, excitatory neurotransmitter (AB120049)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - L-Glutamate, excitatory neurotransmitter (AB120049)

ab55051 staining GABA B receptor 1 in SK-N-SH cells treated with L-Glutamate (ab120049), by ICC/IF. Internalization of GABA B receptor 1 correlates with increased concentration of L-Glutamate, as described in literature.
The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120049 (L-Glutamate) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab55051 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - L-Glutamate, excitatory neurotransmitter (AB120049)
  • Chemical Structure

Lab

Chemical Structure - L-Glutamate, excitatory neurotransmitter (AB120049)

2D chemical structure image of ab120049, L-Glutamate, excitatory neurotransmitter

Key facts

CAS number

56-86-0

Purity

>99%

Form

Solid

form

Molecular weight

147.13 Da

Molecular formula

C<sub>5</sub>H<sub>9</sub>NO<sub>4</sub>

PubChem

33032

Nature

Synthetic

Solubility

Soluble in 1 eq. NaOH to 100 mM

Soluble in water to 25mM

Biochemical name

Glutamic Acid

Biological description

Major excitatory neurotransmitter. Acts at glutamate receptors. Active in vivo.

Canonical smiles

C(CC(=O)O)C(C(=O)O)N

Isomeric smiles

C(CC(=O)O)[C@@H](C(=O)O)N

InChi

InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChiKey

WHUUTDBJXJRKMK-VKHMYHEASA-N

IUPAC Name

(2S)-2-aminopentanedioic acid

style
left-column

Complementary Products

Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

  • 0
  • 0
Assay Kits

AB83389

Glutamate Assay Kit

Functional Studies - Glutamate Assay Kit (AB83389)

  • 4
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Assay Kits

AB113851

DCFDA / H2DCFDA - Cellular ROS Assay Kit

Cellular Activity - DCFDA / H2DCFDA - Cellular ROS Assay Kit (AB113851)

  • 5
  • 11
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:15051 PubMed40301465

2025

ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Erika Di Biase,Kyle J Connolly,Ingrid Crumpton,Oliver Cooper,Penelope J Hallett,Ole Isacson

International journal of molecular sciences 25: PubMed38397098

2024

Novel Immortalized Human Multipotent Mesenchymal Stromal Cell Line for Studying Hormonal Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Primak,Natalia Kalinina,Mariya Skryabina,Vladimir Usachev,Vadim Chechekhin,Maksim Vigovskiy,Elizaveta Chechekhina,Nikita Voloshin,Konstantin Kulebyakin,Maria Kulebyakina,Olga Grigorieva,Pyotr Tyurin-Kuzmin,Nataliya Basalova,Anastasia Efimenko,Stalik Dzhauari,Yulia Antropova,Ivan Plyushchii,Zhanna Akopyan,Veronika Sysoeva,Vsevolod Tkachuk,Maxim Karagyaur

Frontiers in endocrinology 13:986131 PubMed36313740

2022

The neuroprotective effect of melatonin in glutamate excitotoxicity of R28 cells and mouse retinal ganglion cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Wang,Yaqiong An,Zhaohua Xia,Xuezhi Zhou,Haibo Li,Shuang Song,Lexi Ding,Xiaobo Xia

Frontiers in cell and developmental biology 10:844378 PubMed35646890

2022

Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Hu,Cao Chen,Ying Xia,Jia Chen,Wei Yang,Lin Wang,Dong-Dong Chen,Yue-Zhang Wu,Qin Fan,Xiao-Xi Jia,Kang Xiao,Qi Shi,Zhi-Bao Chen,Xiao-Ping Dong

Cell metabolism 33:2428-2444.e8 PubMed34710355

2021

Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Zhao,Jason Karpac

eLife 10: PubMed34369877

2021

Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Chong Guo,Stephanie Rudolph,Morgan E Neuwirth,Wade G Regehr

Cancer discovery 11:446-479 PubMed33127842

2020

Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression.

Applications

Unspecified application

Species

Unspecified reactive species

Ralph Francescone,Débora Barbosa Vendramini-Costa,Janusz Franco-Barraza,Jessica Wagner,Alexander Muir,Allison N Lau,Linara Gabitova,Tatiana Pazina,Sapna Gupta,Tiffany Luong,Dustin Rollins,Ruchi Malik,Roshan J Thapa,Diana Restifo,Yan Zhou,Kathy Q Cai,Harvey H Hensley,Yinfei Tan,Warren D Kruger,Karthik Devarajan,Siddharth Balachandran,Andres J Klein-Szanto,Huamin Wang,Wafik S El-Deiry,Matthew G Vander Heiden,Suraj Peri,Kerry S Campbell,Igor Astsaturov,Edna Cukierman

Cell metabolism 32:259-272.e10 PubMed32531201

2020

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain.

Applications

Unspecified application

Species

Unspecified reactive species

Chaitali Mukherjee,Tina Kling,Belisa Russo,Kerstin Miebach,Eva Kess,Martina Schifferer,Liliana D Pedro,Ulrich Weikert,Maryam K Fard,Nirmal Kannaiyan,Moritz Rossner,Marie-Louise Aicher,Sandra Goebbels,Klaus-Armin Nave,Eva-Maria Krämer-Albers,Anja Schneider,Mikael Simons

Frontiers in neuroscience 13:1098 PubMed31680833

2019

Calsyntenin-1 Negatively Regulates ICAM5 Accumulation in Postsynaptic Membrane and Influences Dendritic Spine Maturation in a Mouse Model of Fragile X Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Ke Cheng,Yu-Shan Chen,Chao-Xiong Yue,Si-Ming Zhang,Ya-Ping Pei,Gui-Rong Cheng,Dan Liu,Lang Xu,Hong-Xin Dong,Yan Zeng

The International journal of developmental biology 61:665-681 PubMed29319115

2018

Amphioxus photoreceptors - insights into the evolution of vertebrate opsins, vision and circadian rhythmicity.

Applications

Unspecified application

Species

Unspecified reactive species

Jiri Pergner,Zbynek Kozmik
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com