JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB146130

L-(-)-threo-3-Hydroxyaspartic acid, EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor

Be the first to review this product! Submit a review

|

(0 Publication)

MW 149.1 Da, Purity >97%. Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Potentiates L-glutamate (ab120049) and L-aspartate induced neuronal excitation. Shows neuronal excitotoxic effects in vivo. .

View Alternative Names

EA6, EAA1_HUMAN, EAA2_HUMAN, EAA3_HUMAN, EAAC 1, EAAT2, Excitatory amino acid transporter 1, Excitatory amino acid transporter 2, Excitatory amino acid transporter 3, Excitatory amino acid transporter 4, Excitatory amino-acid carrier 1, FLJ25094, GLAST, GLAST-1, GLT-1, GLUTAMATE TRANSPORTER, HIGH-AFFINITY, Glial high affinity glutamate transporter, Glutamate/aspartate transporter II, High affinity neuronal glutamate transporter, MEAAC 1, MGC33092, MGC43671, Neuronal and epithelial glutamate transporter, REAAC 1, SLC1A1, SOLUTE CARRIER FAMILY 1 (NEURONAL/EPITHELIAL HIGH AFFINITY GLUTAMATE TRANSPORTER), MEMBER 1, Slc1 a1, Slc1a 1, Slc1a2, Slc1a3, Sodium dependent glutamate/aspartate transporter, Sodium-dependent glutamate/aspartate transporter 1, Sodium-dependent glutamate/aspartate transporter 2, Sodium-dependent glutamate/aspartate transporter 3, Solute carrier family 1 (glial high affinity glutamate transporter) member 3, Solute carrier family 1 (high affinity aspartate/glutamate transporter) member 6, Solute carrier family 1 (neuronal / epithelial high affinity glutamate transporter, system Xag), member 1, Solute carrier family 1 member 1, Solute carrier family 1 member 2, Solute carrier family 1 member 3, Solute carrier family 1 member 6, glutamate/aspartate transporter, high affinity, sodium-dependent

1 Images
Chemical Structure - L-(-)-threo-3-Hydroxyaspartic acid, EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor (AB146130)
  • Chemical Structure

Lab

Chemical Structure - L-(-)-threo-3-Hydroxyaspartic acid, EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor (AB146130)

2D chemical structure image of ab146130, L-(-)-threo-3-Hydroxyaspartic acid, EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor

Key facts

CAS number

7298-99-9

Purity

>97%

Form

Solid

form

Molecular weight

149.1 Da

Molecular formula

C<sub>4</sub>H<sub>7</sub>NO<sub>5</sub>

PubChem

443239

Nature

Synthetic

Solubility

Soluble in 1eq. NaOH to 100 mM

Biochemical name

DL-threo-beta-Hydroxyaspartic acid

Biological description

Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Potentiates L-glutamate (ab120049) and L-aspartate induced neuronal excitation. Shows neuronal excitotoxic effects in vivo.

Canonical smiles

C(C(C(=O)O)O)(C(=O)O)N

Isomeric smiles

[C@H]([C@@H](C(=O)O)O)(C(=O)O)N

InChi

InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1

InChiKey

YYLQUHNPNCGKJQ-LWMBPPNESA-N

IUPAC Name

(2S,3S)-2-amino-3-hydroxybutanedioic acid

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glutamate Transporter 1 also known as EAAT3 and EAAT4 is involved in the transport of glutamate across cell membranes. This protein family is essential in maintaining low extracellular levels of glutamate in the central nervous system. The members of this family have different expression patterns with EAAT3 mostly found in neurons EAAT4 found in cerebellar Purkinje cells and EAAT1 in astrocytes. These transporters have a mass ranging from approximately 50 to 60 kDa.
Biological function summary

The glutamate transporters remove glutamate from the synaptic cleft preventing excitotoxicity which occurs when excessive glutamate leads to neuronal damage. They comprise part of a larger protein complex that maintains synaptic transmission and cellular homeostasis. These transporters also regulate excitatory signaling and help recycle glutamate for use as a neurotransmitter maintaining brain function.

Pathways

Glutamate transporters integrate into the glutamatergic signaling pathway important in synaptic transmission and plasticity. They play a role in the central nervous system interacting with proteins involved in neurotransmitter release such as glutamine synthetase which assists in converting glutamate back into glutamine. These transporters also connect to pathways managing metabolic energy highlighting their influence beyond neurotransmission alone.

Changes in glutamate transporter activity relate to neurological conditions like epilepsy and amyotrophic lateral sclerosis (ALS). Dysregulation might result in altered excitatory signaling contributing to neuron damage and disease progression. The transporters connect to other proteins involved in these disorders such as those in the astrocytic pathways that support neuronal health and neurotransmitter balance.
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Biochemicals

AB120272

Riluzole (PK 26124), GABA uptake inhibitor

Chemical Structure - Riluzole (PK 26124), GABA uptake inhibitor (AB120272)

  • 0
  • 0
Biochemicals

AB120309

UCPH-101, Selective EAAT1 inhibitor

Chemical Structure - UCPH-101, Selective EAAT1 inhibitor (AB120309)

  • 0
  • 0
Biochemicals

AB146404

UCPH-102, EAAT1 inhibitor

Functional Studies - UCPH-102, EAAT1 inhibitor (AB146404)

  • 0
  • 0
Primary Antibodies

AB245230

Anti-BRN3A antibody [EPR23257-285]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Western blot - Anti-BRN3A antibody [EPR23257-285] (AB245230)

  • 5
  • 2

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com