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AB144070

L-threo-Dihydrosphingosine (Safingol), lyso-sphingolipid PKC inhibitor

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(1 Publication)

MW 301.5 Da, Purity >98%. Cell-permeable, reversible lyso-sphingolipid protein kinase C (PKC) inhibitor (IC50 = 40 μM). Anticancer agent. Potentiates effect of Doxorubicin (DOX) (ab120629) in tumor-bearing animals and cytotoxicity ofMitomycin C (ab120797) in cancer cells. Active in vivo and in vitro.

Key facts

CAS number

15639-50-6

Purity

>98%

Molecular weight

301.5 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>3</sub><sub>9</sub>NO<sub>2</sub>

PubChem

3058739

Nature

Synthetic

Solubility

Soluble in ethanol

Soluble in DMSO to 5 mM

Biochemical name

Safingol

Biological description

Cell-permeable, reversible lyso-sphingolipid protein kinase C (PKC) inhibitor (IC50 = 40 μM). Anticancer agent. Potentiates effect of Doxorubicin (DOX) (ab120629) in tumor-bearing animals and cytotoxicity ofMitomycin C (ab120797) in cancer cells. Active in vivo and in vitro.

Canonical smiles

CCCCCCCCCCCCCCCC(C(CO)N)O

Isomeric smiles

CCCCCCCCCCCCCCC[C@@H]([C@H](CO)N)O

InChi

InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18-/m0/s1

InChiKey

OTKJDMGTUTTYMP-ROUUACIJSA-N

IUPAC Name

(2S,3S)-2-aminooctadecane-1,3-diol

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Complementary Products

Biochemicals

AB120158

E-4031 dihydrochloride, HERG K+ channel blocker

Chemical Structure - E-4031 dihydrochloride, HERG K+ channel blocker (AB120158)

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Biochemicals

AB120503

BAPTA-AM, Ca2+ chelator

Immunocytochemistry/ Immunofluorescence - BAPTA-AM, Ca2+ chelator (AB120503)

  • 0
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Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

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Primary Antibodies

AB133741

Anti-Lamin B1 antibody [EPR8985(B)] - Nuclear Envelope Marker

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Lamin B1 antibody [EPR8985(B)] - Nuclear Envelope Marker (AB133741)

  • 4
  • 15
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Annals of translational medicine 9:1470 PubMed34734022

2021

Cold-inducible RNA-binding protein migrates from the nucleus to the cytoplasm under cold stress in normal human bronchial epithelial cells via TRPM8-mediated mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Liang-Ping Mao,Yan Jiao,Jian-Hua Xiang,Xin-Wei Luo,Qian He,Dan-Hua Ran,Qing Xu,Chun-Hui Lang,Ling-Xiu Chen
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