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AB141411

Lactacystin, proteasome inhibitor

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(6 Publications)

MW 376.4 Da, Purity >95%. Potent, irreversible, cell-permeable, selective 20S proteasome inhibitor (IC50 = 70 nM). Inhibits cell-cycle progression and induces neurite outgrowth in vitro. Anti-bacterial and antitumor agent. Active in vivo and in vitro.
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Chemical Structure - Lactacystin, proteasome inhibitor (AB141411)
  • Chemical Structure

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Chemical Structure - Lactacystin, proteasome inhibitor (AB141411)

2D chemical structure image of ab141411, Lactacystin, proteasome inhibitor

Key facts

CAS number

133343-34-7

Purity

>95%

Molecular weight

376.4 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>4</sub>N<sub>2</sub>O<sub>7</sub>S

PubChem

3870

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

2-(Acetylamino)-3-[({3-hydroxy-2-[1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)sulfanyl]propanoic acid

Biological description

Potent, irreversible, cell-permeable, selective 20S proteasome inhibitor (IC50 = 70 nM). Inhibits cell-cycle progression and induces neurite outgrowth in vitro. Anti-bacterial and antitumor agent. Active in vivo and in vitro.

Canonical smiles

CC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O

InChi

InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)

InChiKey

DAQAKHDKYAWHCG-UHFFFAOYSA-N

IUPAC Name

2-acetamido-3-[3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1709 Lactacystin (Synthetic). 1709-200 is the same size as the 200 μg size of ab141411.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:1330 PubMed39779794

2025

The E3 ubiquitin ligase MARCH1 mediates downregulation of plasma membrane GABA receptors under ischemic conditions by inhibiting fast receptor recycling.

Applications

Unspecified application

Species

Unspecified reactive species

Musadiq A Bhat,Mohammad Hleihil,Irene Mondéjar,Thomas Grampp,Dietmar Benke

EMBO reports 24:e57145 PubMed37870370

2023

Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models.

Applications

Unspecified application

Species

Unspecified reactive species

Nagendran Ramalingam,Lisa Brontesi,Shan-Xue Jin,Dennis J Selkoe,Ulf Dettmer

Molecular psychiatry : PubMed32051550

2020

A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Silvia Cursano,Chiara R Battaglia,Carolina Urrutia-Ruiz,Stefanie Grabrucker,Michael Schön,Jürgen Bockmann,Sonja Braumüller,Peter Radermacher,Francesco Roselli,Markus Huber-Lang,Tobias M Boeckers

Nature communications 10:1639 PubMed30967557

2019

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Song,Shi Tang,Xiaolei Han,Ziying Jiang,Lingling Dong,Cuicui Liu,Xiaoyan Liang,Jixin Dong,Chengxuan Qiu,Yongxiang Wang,Yifeng Du

International journal of molecular sciences 18: PubMed28902178

2017

Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain.

Applications

Unspecified application

Species

Unspecified reactive species

Hyunkyu Park,Donggeon Kim,Eunmi Kim,Jason K Sa,Hee Won Lee,Suji Yu,Jiwon Oh,Seok-Hyung Kim,Yeup Yoon,Do-Hyun Nam

Cellular physiology and biochemistry : internation 34:691-702 PubMed25171176

2014

Berberine induces hERG channel deficiency through trafficking inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Kaiping Zhang,Duo Zhi,Ting Huang,Yan Gong,Meng Yan,Chen Liu,Ting Wei,Zengxiang Dong,Baoxin Li,Baofeng Yang
View all publications
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