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MW 581.1 Da, Purity >98%. Cell-permeable, potent dual tyrosine kinase inhibitor of EGFR and HER2 (ERBB2) (IC50 values are 3 nM and 13 nM respectively). Also inhibits HER4 (IC50 = 347 nM). Reduces tyrosine phosphorylation of EGFR and HER2, and inhibits activation of Erk1/2 and AKT, downstream effectors of proliferation and cell survival, respectively. Inhibits tumor cell growth in vitro and in xenograft models for a variety of human tumors. Effective in vivo and is used in combination therapy to prevent or suppress cancers where these kinases are over-expressed, including breast cancer.

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Chemical Structure - Lapatinib, EGFR and HER2 tyrosine kinase inhibitor (AB219408), expandable thumbnail

Key facts

CAS number
231277-92-2
Purity
> 98%
Form
Solid
Molecular weight
581.1 Da
Molecular formula
C29H26ClFN4O4S
PubChem identifier
208908
Nature
Synthetic

Target data

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MW 581.1 Da, Purity >98%. Cell-permeable, potent dual tyrosine kinase inhibitor of EGFR and HER2 (ERBB2) (IC50 values are 3 nM and 13 nM respectively). Also inhibits HER4 (IC50 = 347 nM). Reduces tyrosine phosphorylation of EGFR and HER2, and inhibits activation of Erk1/2 and AKT, downstream effectors of proliferation and cell survival, respectively. Inhibits tumor cell growth in vitro and in xenograft models for a variety of human tumors. Effective in vivo and is used in combination therapy to prevent or suppress cancers where these kinases are over-expressed, including breast cancer.

Key facts

Purity
> 98%
PubChem identifier
208908
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
Lapatinib
Biological description

Cell-permeable, potent dual tyrosine kinase inhibitor of EGFR and HER2 (ERBB2) (IC50 values are 3 nM and 13 nM respectively). Also inhibits HER4 (IC50 = 347 nM). Reduces tyrosine phosphorylation of EGFR and HER2, and inhibits activation of Erk1/2 and AKT, downstream effectors of proliferation and cell survival, respectively. Inhibits tumor cell growth in vitro and in xenograft models for a variety of human tumors. Effective in vivo and is used in combination therapy to prevent or suppress cancers where these kinases are over-expressed, including breast cancer.

Canonical SMILES
CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
InChI
InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
InChIKey
BCFGMOOMADDAQU-UHFFFAOYSA-N
IUPAC name
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

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1 product image

  • Chemical Structure - Lapatinib, EGFR and HER2 tyrosine kinase inhibitor (ab219408), expandable thumbnail

    Chemical Structure - Lapatinib, EGFR and HER2 tyrosine kinase inhibitor (ab219408)

    2D chemical structure image of ab219408, Lapatinib, EGFR and HER2 tyrosine kinase inhibitor

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Product protocols

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