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AB144290

Latrunculin A (LAT-A), Actin polymerization inhibitor

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(29 Publications)

Latrunculin A (LAT-A) is an actin polymerization inhibitor. Stabilizes monomeric G-actin and disrupts F-actin organization. Shows greater potency than Latrunculin B (ab144291). MW 421.6

- Inhibits growth of cancer cell lines (IC50 values are 142, 142, 142, 166 and 95 nM for A549, H522-T1, HT-29, U-937 and MDA-MB-43 cells respectively)
- Potent antiproliferative agent
- Available in different sizes to fit your experimental needs

View Alternative Names

ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Basic-helix-loop-helix-PAS protein MOP2, Class E basic helix-loop-helix protein 73, Class E basic helix-loop-helix protein 78, ECYT4, EPAS1_HUMAN, Endothelial PAS domain-containing protein 1, Endothelial pas domain protein 1, HIF-1, HIF-1-alpha, HIF-1-alpha-like factor, HIF-2-alpha, HIF-alpha, HIF1A_HUMAN, HIF2A, Hypoxia inducible factor 1 alpha isoform I.3, Hypoxia inducible factor 1 alpha subunit, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor, Hypoxia inducible factor 1, alpha subunit (basic helix loop helix transcription factor), Hypoxia inducible factor 2 alpha subunit, Hypoxia-inducible factor 1-alpha, Hypoxia-inducible factor 2-alpha, MOP 1, MOP 2, Member of PAS protein 1, Member of PAS protein 2, Member of PAS superfamily 1, Member of pas superfamily 2, Member of the PAS Superfamily 1, PAS domain-containing protein 2, PAS domain-containing protein 8, PASD 8, PASD2, bHLHe73, bHLHe78, hifla

1 Images
Chemical Structure - Latrunculin A (LAT-A), Actin polymerization inhibitor (AB144290)
  • Chemical Structure

Lab

Chemical Structure - Latrunculin A (LAT-A), Actin polymerization inhibitor (AB144290)

2D chemical structure image of ab144290, Latrunculin A (LAT-A), Actin polymerization inhibitor

Key facts

CAS number

76343-93-6

Purity

>95%

Form

Solid

form

Source

Cacospongia mycofijiensis

Molecular weight

421.6 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>3</sub><sub>1</sub>NO<sub>5</sub>S

PubChem

445420

Nature

Native

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 10 mM

Biochemical name

Latrunculin a

Biological description

Actin polymerization inhibitor. Potent antiproliferative agent. Stabilizes monomeric G-actin. Shows greater potency than Latrunculin B (ab144291). Binds actin monomers near the nucleotide binding cleft with 1:1 stoichiometry. Inhibits growth of cancer cell lines (IC50 values are 142, 142, 142, 166 and 95 nM for A549, H522-T1, HT-29, U-937 and MDA-MB-43 cells respectively). Shows convulsant effects in vivo.

Canonical smiles

CC1CCC2CC(CC(O2)(C3CSC(=O)N3)O)OC(=O)C=C(CCC=CC=C1)C

Isomeric smiles

C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C/C=C1)/C

InChi

InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1

InChiKey

DDVBPZROPPMBLW-IZGXTMSKSA-N

IUPAC Name

(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one

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Product details

Check out our range of Actin polymerization inhibitor biochemicals here
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HIF-1 alpha and HIF-2-alpha have associations with cancer and chronic kidney disease. Their unregulated activation is often observed in various cancers promoting an environment that supports tumor growth and survival under hypoxic conditions. In cancers these proteins work closely with VEGF which contributes to angiogenesis and tumor progression. In chronic kidney disease aberrant expression of HIF-1 alpha may influence disease progression by affecting erythropoiesis and iron metabolism linked with proteins like EPO (erythropoietin).
Pathways

HIF-1 alpha and HIF-2-alpha are central to the hypoxia signaling pathway directly affecting genes like VEGF that stimulate blood vessel formation. They interact with proteins such as PHD (prolyl hydroxylase domain proteins) and VHL (von Hippel-Lindau protein) for regulation. These pathways play roles in the cellular adaptation to low oxygen impacting processes such as glucose metabolism and cell survival. They connect with other pathways too like the mTOR pathway influencing protein synthesis and cellular energy use.

Biological function summary

HIF-1 alpha and HIF-2-alpha regulate the transcription of genes involved in angiogenesis metabolism and erythropoiesis among others. When oxygen levels drop these factors stabilise and activate to initiate gene expression changes. They are members of the HIF family and form complexes with ARNT. This functional arrangement serves as a vital response mechanism to hypoxic stress influencing numerous cellular processes and adapting the cell metabolism to changing oxygen availability.

HIF-2-alpha and HIF-1 alpha also known as EPAS1 and HIF1A respectively are subunits of the hypoxia-inducible factors which play major roles in response to low oxygen conditions. They form heterodimeric complexes with the ARNT (aryl hydrocarbon receptor nuclear translocator) to function as transcription factors. HIF-1 alpha has a molecular weight of approximately 120 kDa while HIF-2-alpha's weight is around 118 kDa. Both are mostly expressed in various tissues that are sensitive to oxygen levels including but not limited to the kidney liver and heart.
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Product protocols

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Publications (29)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 99:e0211324 PubMed39907281

2025

The Japanese encephalitis virus NS1 protein concentrates ER membranes in a cytoskeleton-independent manner to facilitate viral replication.

Applications

Unspecified application

Species

Unspecified reactive species

Shengda Xie,Xinxin Lin,Qing Yang,Miaolei Shi,Xingmiao Yang,Ziyu Cao,Ruibing Cao

Cell death and differentiation 32:546-560 PubMed39511403

2024

Localized release of muscle-generated BDNF regulates the initial formation of postsynaptic apparatus at neuromuscular synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Jinkai Zhang,Hiu-Lam Rachel Kwan,Chi Bun Chan,Chi Wai Lee

Journal of virology 98:e0060624 PubMed38809020

2024

RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaomin Liu,Jing Xu,Maolin Zhang,Hualei Wang,Xin Guo,Mingxin Zhao,Ming Duan,Zhenhong Guan,Yidi Guo

Nature communications 15:541 PubMed38225245

2024

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Linnea Z Drexhage,Shengpan Zhang,Maeva Dupont,Franziska Ragaller,Ellen Sjule,Jose Cabezas-Caballero,Lachlan P Deimel,Helen Robertson,Rebecca A Russell,Omer Dushek,Erdinc Sezgin,Niloofar Karaji,Quentin J Sattentau

Current biology : CB 34:245-259.e8 PubMed38096821

2023

Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration.

Applications

Unspecified application

Species

Unspecified reactive species

Weiyi Qian,Naoya Yamaguchi,Patrycja Lis,Michael Cammer,Holger Knaut

Biophysical journal 122:767-783 PubMed36739478

2023

Vast heterogeneity in cytoplasmic diffusion rates revealed by nanorheology and Doppelgänger simulations.

Applications

Unspecified application

Species

Unspecified reactive species

Rikki M Garner,Arthur T Molines,Julie A Theriot,Fred Chang

Advanced healthcare materials 12:e2201720 PubMed36447307

2022

Delivery of Induced Neural Stem Cells Through Mechano-Tuned Silk-Collagen Hydrogels for the Recovery of Contused Spinal Cord in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Ganchimeg Davaa,Jin Young Hong,Jung-Hwan Lee,Min Soo Kim,Jennifer O Buitrago,Yu-Meng Li,Hae-Hyoung Lee,Dong Wook Han,Kam W Leong,Jung Keun Hyun,Hae-Won Kim

eLife 11: PubMed36111670

2022

Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Judith Pineau,Léa Pinon,Olivier Mesdjian,Jacques Fattaccioli,Ana-Maria Lennon Duménil,Paolo Pierobon

Cancer research communications 2:914-928 PubMed36922934

2022

The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand-dependent Cancer Models.

Applications

Unspecified application

Species

Unspecified reactive species

Caroline Phillips,Inder Bhamra,Catherine Eagle,Eimear Flanagan,Richard Armer,Clifford D Jones,Matilda Bingham,Peter Calcraft,Alicia Edmenson Cook,Ben Thompson,Simon A Woodcock

The Journal of cell biology 221: PubMed35575797

2022

Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton.

Applications

Unspecified application

Species

Unspecified reactive species

Leiling Shi,Youli Jian,Meijiao Li,Tianchao Hao,Chonglin Yang,Xiaochen Wang
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