MW 395.5 Da, Purity >96%. Cell-permeable actin polymerization inhibitor. Forms a 1:1 complex with monomeric G-actin. Shows less potent growth inhibition effects on cancer cell lines than Latrunculin A, (ab144290) (IC50 values are 7.1 and 4.8 μM for HCT116 and MDA-MB-435 cells respectively). Shows antiglaucoma effects in vivo. .
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- Investigative ophthalmology & visual science 64:262023Norepinephrine as the Intrinsic Contributor to Contact Lens-Induced Pseudomonas aeruginosa Keratitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBi Ning Zhang,Benxiang Qi,Wai Kit Chu,Fangying Song,Suxia Li,Qiaoqiao Dong,Zheng Shao,Bin Zhang,Xianli Du,Xiubin Ma,Vishal Jhanji,Qingjun ZhouPubMed 37234000
- iScience 26:1074582023Myo1d promotes alpha-synuclein transfer from brain microvascular endothelial cells to pericytes through tunneling nanotubes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQingrui Duan,Qingxi Zhang,Kun Nie,Rui Huang,Jianhua Yang,Peikun He,Zihui Tie,Haifeng Huang,Guixian Ma,Yuhu Zhang,Yuyuan Gao,Lijuan WangPubMed 37575183
- The Journal of cell biology 222:2023Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFemmy C Stempels,Muwei Jiang,Harry M Warner,Magda-Lena Moser,Maaike H Janssens,Sjors Maassen,Iris H Nelen,Rinse de Boer,William F Jiemy,David Knight,Julian Selley,Ronan O'Cualain,Maksim V Baranov,Thomas C Q Burgers,Roberto Sansevrino,Dragomir Milovanovic,Peter Heeringa,Matthew C Jones,Rifka Vlijm,Martin Ter Beest,Geert van den BogaartPubMed 37200023
- EMBO reports 24:e546002023Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnukriti Mathur,Callum Kay,Yansong Xue,Abhimanu Pandey,Jiwon Lee,Weidong Jing,Daniel Enosi Tuipulotu,Jordan Lo Pilato,Shouya Feng,Chinh Ngo,Anyang Zhao,Cheng Shen,Melanie Rug,Lisa A Miosge,Ines I Atmosukarto,Jason D Price,Sidra A Ali,Elizabeth E Gardiner,Avril Ab Robertson,Milena M Awad,Dena Lyras,Nadeem O Kaakoush,Si Ming ManPubMed 37073791
- Research (Washington, D.C.) 6:00542023Microtubule Assists Actomyosin to Regulate Cell Nuclear Mechanics and Chromatin Accessibility.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiwen Geng,Zhefeng Kang,Qian Sun,Man Zhang,Peng Wang,Yupei Li,Jiameng Li,Baihai Su,Qiang WeiPubMed 37040508
- Life science alliance 6:2023Multiple phosphorylation of the Cdc48/p97 cofactor protein Shp1/p47 occurs upon cell stress in budding yeast.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexander Agrotis,Frederic Lamoliatte,Thomas D Williams,Ailsa Black,Rhuari Horberry,Adrien RousseauPubMed 36693698
- EMBO reports 23:e552512022Two-step nuclear centring by competing microtubule- and actin-based mechanisms in 2-cell mouse embryos.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYunan Ye,Hayden A HomerPubMed 36214648
- Cell reports 40:1111022022Rapid macropinocytic transfer of α-synuclein to lysosomes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesArmin Bayati,Emily Banks,Chanshuai Han,Wen Luo,Wolfgang E Reintsch,Cornelia E Zorca,Irina Shlaifer,Esther Del Cid Pellitero,Benoit Vanderperre,Heidi M McBride,Edward A Fon,Thomas M Durcan,Peter S McPhersonPubMed 35858558
- Nature cell biology 24:1077-10872022Actin remodelling controls proteasome homeostasis upon stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesThomas David Williams,Roberta Cacioppo,Alexander Agrotis,Ailsa Black,Houjiang Zhou,Adrien RousseauPubMed 35739319
- eLife 11:2022Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao-Dong Fang,Qiang Gao,Ying Zang,Ji-Hui Qiao,Dong-Min Gao,Wen-Ya Xu,Ying Wang,Dawei Li,Xian-Bing WangPubMed 35191833
Key facts
- CAS number
- 76343-94-7
- Purity
- > 96%
- Form
- Solid
- Source
- Latrunculia magnifica
- Molecular weight
- 395.5 Da
- Molecular formula
- C20H29NO5S
- PubChem identifier
- 6436219
- Nature
- Native
Target data
Recommended products
MW 395.5 Da, Purity >96%. Cell-permeable actin polymerization inhibitor. Forms a 1:1 complex with monomeric G-actin. Shows less potent growth inhibition effects on cancer cell lines than Latrunculin A, (ab144290) (IC50 values are 7.1 and 4.8 μM for HCT116 and MDA-MB-435 cells respectively). Shows antiglaucoma effects in vivo. .
Key facts
- CAS number
- 76343-94-7
- Purity
- > 96%
- Form
- Solid
- Source
- Latrunculia magnifica
- Molecular weight
- 395.5 Da
- Molecular formula
- C20H29NO5S
- PubChem identifier
- 6436219
- Nature
- Native
- Solubility
Soluble in DMSO (25 mg/ml).
Soluble in ethanol (25 mg/ml).
- Biochemical name
- latrunculin B
- Biological description
Cell-permeable actin polymerization inhibitor. Forms a 1:1 complex with monomeric G-actin. Shows less potent growth inhibition effects on cancer cell lines than Latrunculin A, (ab144290) (IC50 values are 7.1 and 4.8 μM for HCT116 and MDA-MB-435 cells respectively). Shows antiglaucoma effects in vivo.
- Canonical SMILES
- CC1CCC2CC(CC(O2)(C3CSC(=O)N3)O)OC(=O)C=C(CCC=C1)C
- Isomeric SMILES
- C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C1)/C
- InChI
- InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
- InChIKey
- NSHPHXHGRHSMIK-JRIKCGFMSA-N
- IUPAC name
- (4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
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1 product image
Chemical Structure - Latrunculin B, actin polymerization inhibitor (ab144291)
2D chemical structure image of ab144291, Latrunculin B, actin polymerization inhibitor
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