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AB273616

LCL161

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MW 500.6 Da, Purity >99%. Small molecule SMAC mimetic inhibitor of multiple IAP (Inhibitor of apoptosis) family proteins. (IC50 = 10.23 μM). Inhibits cell proliferation and viability in two human hepatocellular carcinoma cells (Hep3B, IC50 = 10, and PLC5, IC50 = 19).
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Chemical Structure - LCL161 (AB273616)
  • Chemical Structure

Lab

Chemical Structure - LCL161 (AB273616)

Chemical structure of LCL161, 1005342-46-0

Key facts

CAS number

1005342-46-0

Purity

>99%

Form

Solid

form

Molecular weight

500.6 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>3</sub><sub>3</sub>FN<sub>4</sub>O<sub>3</sub>S

PubChem

24737642

Nature

Synthetic

Biochemical name

Lcl-161

Biological description

Small molecule SMAC mimetic inhibitor of multiple IAP (Inhibitor of apoptosis) family proteins. (IC50 = 10.23 μM). Inhibits cell proliferation and viability in two human hepatocellular carcinoma cells (Hep3B, IC50 = 10, and PLC5, IC50 = 19).

Canonical smiles

CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC

Isomeric smiles

C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC

InChi

InChI=1S/C26H33FN4O3S/c1-16(28-2)24(33)30-22(17-7-4-3-5-8-17)26(34)31-14-6-9-21(31)25-29-20(15-35-25)23(32)18-10-12-19(27)13-11-18/h10-13,15-17,21-22,28H,3-9,14H2,1-2H3,(H,30,33)/t16-,21-,22-/m0/s1

InChiKey

UFPFGVNKHCLJJO-SSKFGXFMSA-N

IUPAC Name

(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide

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Product details

For obtaining a higher solubility, please warm the tube at 37°C and shake in the ultrasonic bath for a while.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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