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AB278073

LDN 193189 dihydrochloride

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(3 Publications)

MW 479.4 Da, Purity >99%. Potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.

Key facts

CAS number

1435934-00-1

Purity

>99%

Form

Solid

form

Molecular weight

479.4 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>2</sub><sub>4</sub>Cl<sub>2</sub>N<sub>6</sub>

PubChem

91900717

Nature

Synthetic

Solubility

Soluble in water to 10 mM

Biochemical name

LDN 193189 dihydrochloride

Biological description

Potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.

Canonical smiles

C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl.Cl

InChi

InChI=1S/C25H22N6.2ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;;/h1-10,15-17,26H,11-14H2;2*1H

InChiKey

CMQXLLAILGGLRV-UHFFFAOYSA-N

IUPAC Name

4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;dihydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

American journal of stem cells 2:119-31 PubMed23862100

2013

A robust method to derive functional neural crest cells from human pluripotent stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Faith R Kreitzer,Nathan Salomonis,Alice Sheehan,Miller Huang,Jason S Park,Matthew J Spindler,Paweena Lizarraga,William A Weiss,Po-Lin So,Bruce R Conklin

Nature biotechnology 30:715-20 PubMed22750882

2012

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors.

Applications

Unspecified application

Species

Unspecified reactive species

Stuart M Chambers,Yuchen Qi,Yvonne Mica,Gabsang Lee,Xin-Jun Zhang,Lei Niu,James Bilsland,Lishuang Cao,Edward Stevens,Paul Whiting,Song-Hai Shi,Lorenz Studer

Nature medicine 14:1363-9 PubMed19029982

2008

BMP type I receptor inhibition reduces heterotopic [corrected] ossification.

Applications

Unspecified application

Species

Unspecified reactive species

Paul B Yu,Donna Y Deng,Carol S Lai,Charles C Hong,Gregory D Cuny,Mary L Bouxsein,Deborah W Hong,Patrick M McManus,Takenobu Katagiri,Chetana Sachidanandan,Nobuhiro Kamiya,Tomokazu Fukuda,Yuji Mishina,Randall T Peterson,Kenneth D Bloch
View all publications
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