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MW 397.6 Da, Purity >98%. Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.

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Images

Chemical Structure - LDN-57444, UCH-L1 inhibitor (AB141487), expandable thumbnail

Key facts

CAS number
668467-91-2
Purity
> 98%
Form
Solid
Molecular weight
397.6 Da
Molecular formula
C17H11Cl3N2O3
PubChem identifier
16760696
Nature
Synthetic

Target data

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MW 397.6 Da, Purity >98%. Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.

Key facts

Purity
> 98%
PubChem identifier
16760696
Solubility

Soluble in DMSO to 50 mM.

Biochemical name
(Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
Biological description

Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.

Canonical SMILES
CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
Isomeric SMILES
CC(=O)O/N=C\1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
InChI
InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
InChIKey
OPQRFPHLZZPCCH-PGMHBOJBSA-N
IUPAC name
[(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2016 LDN-57444. 2016-25 is the same size as the 25 mg size of ab141487.

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1 product image

  • Chemical Structure - LDN-57444, UCH-L1 inhibitor (ab141487), expandable thumbnail

    Chemical Structure - LDN-57444, UCH-L1 inhibitor (ab141487)

    2D chemical structure image of ab141487, LDN-57444, UCH-L1 inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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