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AB141487

LDN-57444, UCH-L1 inhibitor

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MW 397.6 Da, Purity >98%. Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.
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Chemical Structure - LDN-57444, UCH-L1 inhibitor (AB141487)
  • Chemical Structure

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Chemical Structure - LDN-57444, UCH-L1 inhibitor (AB141487)

2D chemical structure image of ab141487, LDN-57444, UCH-L1 inhibitor

Key facts

CAS number

668467-91-2

Purity

>98%

Form

Solid

form

Molecular weight

397.6 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>1</sub>Cl<sub>3</sub>N<sub>2</sub>O<sub>3</sub>

PubChem

16760696

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

(Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one

Biological description

Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.

Canonical smiles

CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl

Isomeric smiles

CC(=O)O/N=C\1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl

InChi

InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-

InChiKey

OPQRFPHLZZPCCH-PGMHBOJBSA-N

IUPAC Name

[(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2016 LDN-57444. 2016-25 is the same size as the 25 mg size of ab141487.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Product promise

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