Leelamine, Pyruvate dehydrogenase kinase (PDK) inhibitor

Key facts

CAS number

1446-61-3

Purity

>98%

Form

Liquid

form

Molecular weight

285.47 g/mol

Molecular formula

C₂₀H₃₁N

Nature

Synthetic

Biological description

Pyruvate dehydrogenase kinase (PDK) inhibitor (IC₅₀ = 9.5 μM). It has weak affinity for human CB₁ and CB₂ receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 μM.

Isomeric smiles

CC(C)C(C=C1)=CC2=C1[C@]3(C)[C@](CC2)([H])[C@@](CN)(C)CCC3

IUPAC Name

(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine