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MW 540.7 Da, Purity >95%. Potent inhibitor of CRM-1-mediated (exportin-1) nuclear export. Displays antibiotic, antifungal, and antitumor properties and blocks the cell cycle at G1 and G2 phases. Potent inhibitor of nucleo-cytoplasmic translocation of Rev. Also shown to suppress HIV-1 replication in human monocytes (IC50 = 600 pM).
Alternative names=CRM1 homolog, Chromosome region maintenance 1 protein homolog, DKFZp686B1823, Exp 1, Exportin-1, XPO1_HUMAN
- CAS number
87081-35-4
- Purity
> 95%
- Form
Liquid
- Source
Steptomyces sp.
- Molecular weight
540.7 Da
- Molecular formula
C33H48O6
- PubChem identifier
6917907
- Nature
Native
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MW 540.7 Da, Purity >95%. Potent inhibitor of CRM-1-mediated (exportin-1) nuclear export. Displays antibiotic, antifungal, and antitumor properties and blocks the cell cycle at G1 and G2 phases. Potent inhibitor of nucleo-cytoplasmic translocation of Rev. Also shown to suppress HIV-1 replication in human monocytes (IC50 = 600 pM).
Alternative names=CRM1 homolog, Chromosome region maintenance 1 protein homolog, DKFZp686B1823, Exp 1, Exportin-1, XPO1_HUMAN
Key facts
- CAS number
87081-35-4
- Purity
> 95%
- Form
Liquid
- Source
Steptomyces sp.
- Molecular weight
540.7 Da
- Molecular formula
C33H48O6
- PubChem identifier
6917907
- Nature
Native
- Biochemical name
Leptomycin B
- Biological description
Potent inhibitor of CRM-1-mediated (exportin-1) nuclear export. Displays antibiotic, antifungal, and antitumor properties and blocks the cell cycle at G1 and G2 phases. Potent inhibitor of nucleo-cytoplasmic translocation of Rev. Also shown to suppress HIV-1 replication in human monocytes (IC50 = 600 pM).
- Canonical SMILES
CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C
- Isomeric SMILES
CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
- InChI
InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
- InChIKey
YACHGFWEQXFSBS-XYERBDPFSA-N
- IUPAC name
(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions
Notes
Supplied in ethanol (25 μg/ml).
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