Levofloxacin, Fluoroquinolone antibiotic

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TDP1 is also known as tyrosyl-DNA phosphodiesterase 1. This enzyme plays an important role in repairing DNA by resolving topoisomerase I-DNA covalent complexes. TDP1 has a molecular mass of approximately 68 kDa. It is expressed in various tissues with notable levels in human brain heart and testis. RCE1 which stands for Ras converting enzyme 1 is involved in the processing of CAAX proteins by cleaving the C-terminal peptide. RCE1 has a molecular mass of 35 kDa and is mainly found in cellular membranes. MATE-1 or multidrug and toxin extrusion protein 1 functions as an efflux transporter and is located in various tissues including liver and kidney.

Biological function summary

TDP1 supports genomic stability by hydrolyzing the phosphodiester bond between the tyrosine of topoisomerase I and DNA. This process is critical for the accuracy of replication machinery. RCE1 processes important signaling proteins such as Ras which affects cellular growth and differentiation. MATE-1 on the other hand exports organic cations and metabolites out of cells including antibiotic fluoroquinolone belonging to the fluoroquinolone structure group. None of these proteins are typically part of a complex but act individually to fulfill their roles.

Pathways

TDP1 interacts within the DNA repair pathway particularly homologous recombination and non-homologous end joining. It works closely with proteins like topoisomerase I and PARP1. RCE1 participates in post-translational modification pathways altering proteins like Ras and Rho which are important in signal transduction pathways. MATE-1 integrates within excretion and detoxification pathways acting alongside transporters such as the organic cation transporter family.

TDP1 mutations have been linked to neurodegenerative conditions including spinocerebellar ataxia with axonal neuropathy (SCAN1). The protein's role in DNA repair connects it to other DNA damage response proteins like ATM. Deficiencies in RCE1 function can impact Ras-mediated signaling contributing to oncogenesis and cancer progression. MATE-1 variations influence drug pharmacokinetics and have implications for treatments involving antibiotic fluoroquinolone and other drugs connecting it to transporter proteins like OCT1.