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AB141575

LFM-A13, BTK inhibitor

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MW 360 Da, Purity >97%. Selective Bruton's tyrosine kinase (BTK) inhibitor (IC50 = 2.5 μM). Also inhibits polio-like kinase (Plk1) (IC50 = 37.36 μM). Does not effect EGF receptor, insulin recptor, JAK-1 JAK-2, JAK-3, SYK or HCK (IC50 values are all >300 μM). Anticancer and antileukemic agent. Active in vivo.
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Chemical Structure - LFM-A13, BTK inhibitor (AB141575)
  • Chemical Structure

Lab

Chemical Structure - LFM-A13, BTK inhibitor (AB141575)

2D chemical structure image of ab141575, LFM-A13, BTK inhibitor

Key facts

CAS number

62004-35-7

Purity

>97%

Form

Solid

form

Molecular weight

360 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>8</sub>Br<sub>2</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

54686938

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

Biological description

Selective Bruton's tyrosine kinase (BTK) inhibitor (IC50 = 2.5 μM). Also inhibits polio-like kinase (Plk1) (IC50 = 37.36 μM). Does not effect EGF receptor, insulin recptor, JAK-1 JAK-2, JAK-3, SYK or HCK (IC50 values are all >300 μM). Anticancer and antileukemic agent. Active in vivo.

Canonical smiles

CC(=C(C#N)C(=O)NC1=C(C=CC(=C1)Br)Br)O

InChi

InChI=1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)

InChiKey

UVSVTDVJQAJIFG-UHFFFAOYSA-N

IUPAC Name

2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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