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AB285404

LGK974

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MW 396.4 Da, Purity >98%. LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.

Key facts

CAS number

1243244-14-5

Purity

>98%

Form

Solid

form

Molecular weight

396.4 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>0</sub>N<sub>6</sub>O

PubChem

46926973

Nature

Synthetic

Solubility

DMSO (~35 mg/ml)

Biochemical name

2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

Biological description

LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.

Canonical smiles

CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4

InChi

InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)

InChiKey

XXYGTCZJJLTAGH-UHFFFAOYSA-N

IUPAC Name

2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB68167

Anti-Sarcomeric Alpha Actinin antibody [EP2529Y]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sarcomeric Alpha Actinin antibody [EP2529Y] (AB68167)

  • 5
  • 9
Biochemicals

AB144613

PNU 74654, Wnt signaling pathway blocker

Chemical Structure - PNU 74654, Wnt signaling pathway blocker (AB144613)

  • 0
  • 0
Biochemicals

AB120897

XAV939, Tankyrase inhibitor

Immunocytochemistry/ Immunofluorescence - XAV939, Tankyrase inhibitor (AB120897)

  • 0
  • 0
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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2645 LGK974. 2645-1 is the same size as the 1 mg size of ab285404.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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Product promise

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