JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB235456

Lifitegrast, LFA-1 (lymphocyte function-associated antigen-1) antagonist

Be the first to review this product! Submit a review

|

(0 Publication)

MW 615.48 g/mol, Purity >98%. LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It acts as a molecular decoy to block the LFA-1/ICAM-1 interaction and thus inhibits downstream inflammatory responses.

Key facts

CAS number

1025967-78-5

Purity

>98%

Form

Solid

form

Molecular weight

615.48 g/mol

Molecular formula

C<sub>2</sub><sub>9</sub>H<sub>2</sub><sub>4</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>7</sub>S

Nature

Synthetic

Solubility

DMSO >30 mg/mL

Ethanol 20 mg/mL

Insoluble in water

Biological description

LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It acts as a molecular decoy to block the LFA-1/ICAM-1 interaction and thus inhibits downstream inflammatory responses.

Canonical smiles

CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2CL)C(=O)C4=CC5=C(C=C4)C=CO5)CL

InChi

InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1

InChiKey

JFOZKMSJYSPYLN-QHCPKHFHSA-N

IUPAC Name

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

style
left-column

Complementary Products

Primary Antibodies

AB13219

Anti-CD11+CD18 antibody [24]

  • 4
  • 5
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB259372

Anti-Macrophage Inflammatory Protein 1 alpha / CCL3 + CCL3L1 antibody [EPR23751-54]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Macrophage Inflammatory Protein 1 alpha / CCL3 + CCL3L1 antibody [EPR23751-54] (AB259372)

  • 0
  • 0
Primary Antibodies

AB19580

Anti-CD18 antibody [C71/16]

Recombinant|Trial Size

Flow Cytometry - Anti-CD18 antibody [C71/16] (AB19580)

  • 0
  • 0
style
left-column

Product details

This product is manufactured by BioVision, an Abcam company and was previously called B1917 Lifitegrast. B1917-25 is the same size as the 25 mg size of ab235456.
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com