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AB287002

Liproxstatin-1

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MW 340.8 Da, Purity >98%. A potent inhibitor of ferroptosis. Liproxstatin-1 suppresses ferroptosis in human cells and in an ischemia/reperfusion-induced tissue injury model in mice.
Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.

Key facts

CAS number

950455-15-9

Purity

>98%

Form

Solid

form

Molecular weight

340.8 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>1</sub>ClN<sub>4</sub>

PubChem

135735917

Nature

Synthetic

Solubility

Soluble in DMSO to 25mM

Biochemical name

Liproxstatin-1

Biological description

A potent inhibitor of ferroptosis. Liproxstatin-1 suppresses ferroptosis in human cells and in an ischemia/reperfusion-induced tissue injury model in mice.
Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.

Canonical smiles

C1CNCCC12C(=NCC3=CC(=CC=C3)Cl)NC4=CC=CC=C4N2

InChi

InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)

InChiKey

YAFQFNOUYXZVPZ-UHFFFAOYSA-N

IUPAC Name

N-[(3-chlorophenyl)methyl]spiro[1,4-dihydroquinoxaline-3,4'-piperidine]-2-imine

Product details

This product is manufactured by BioVision, an Abcam company and was previously called B2312 Liproxstatin-1. B2312-5 is the same size as the 5 mg size of ab287002.

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Product protocols

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