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AB300262

LLL12

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(1 Publication)

MW 303.29 Da, Purity >95%. Achieve your results faster with highly validated, pure and trusted compounds.

Key facts

CAS number

1260247-42-4

Purity

>95%

Form

Lyophilized

form

Molecular weight

303.29 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>9</sub>NO<sub>5</sub>S

PubChem

46911017

Nature

Synthetic

Biochemical name

5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide

Canonical smiles

C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C(=CC=C3)S(=O)(=O)N

InChi

InChI=1S/C14H9NO5S/c15-21(19,20)10-6-2-4-8-12(10)14(18)7-3-1-5-9(16)11(7)13(8)17/h1-6,16H,(H2,15,19,20)

InChiKey

CQBHSRLUQDYPBU-UHFFFAOYSA-N

IUPAC Name

5-hydroxy-9,10-dioxoanthracene-1-sulfonamide

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Product details

Protect from air and light.

This product is manufactured by BioVision, an Abcam company and was previously called LLL12, 1792. 1792 is the same size as the 25 mg version of ab300262.

Inhibits Stat3 (Tyr705) phosphorylation. Inhibits Stat3 activity. Downregulates STAT3 downstream targets. Inhibits proliferation and migration of glioblastoma, breast cancer and pancreatic cancer cell lines. Minimal apoptotic effects on normal human cells.

Purity is ≥95% by 1H NMR.

Soluble in DMSO.

CAS number: 1260247-42-4

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Properties and storage information

Shipped at conditions
Blue Ice|+4°C
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neoplasia (New York, N.Y.) 12:39-50 PubMed20072652

2010

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Li Lin,Brian Hutzen,Pui-Kai Li,Sarah Ball,Mingxin Zuo,Stephanie DeAngelis,Elizabeth Foust,Matthew Sobo,Lauren Friedman,Deepak Bhasin,Ling Cen,Chenglong Li,Jiayuh Lin
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