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AB146187

LM11A-31, nonpeptide p75NTR ligand

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MW 316.26 Da. Selective nonpeptide p75NTR ligand. Blocks p75-mediated cell death. Promotes neurogenesis and neurite survival. Does not affect NGF binding to TrkA. Shows neuroprotective and neuroregenerative effects *in vivo.* Orally active. Blood-brain barrier permeable.
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Chemical Structure - LM11A-31, nonpeptide p75NTR ligand (AB146187)
  • Chemical Structure

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Chemical Structure - LM11A-31, nonpeptide p75NTR ligand (AB146187)

2D chemical structure image of ab146187, LM11A-31, nonpeptide p75NTR ligand

Key facts

CAS number

1243259-19-9

Molecular weight

316.26 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>2</sub><sub>7</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>2</sub>

PubChem

91654620

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

LM11A-31 Dihydrochloride

Biological description

Selective nonpeptide p75NTR ligand. Blocks p75-mediated cell death. Promotes neurogenesis and neurite survival. Does not affect NGF binding to TrkA. Shows neuroprotective and neuroregenerative effects *in vivo.* Orally active. Blood-brain barrier permeable.

Canonical smiles

CCC(C)C(C(=O)NCCN1CCOCC1)N.Cl.Cl

Isomeric smiles

CC[C@H](C)[C@@H](C(=O)NCCN1CCOCC1)N.Cl.Cl

InChi

InChI=1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H/t10-,11-;;/m0../s1

InChiKey

LLIHJRRZJDEKLB-ULEGLUPFSA-N

IUPAC Name

(2S,3S)-2-amino-3-methyl-N-(2-morpholin-4-ylethyl)pentanamide;dihydrochloride

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB52642

Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (AB52642)

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Primary Antibodies

AB68428

Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Multiplex immunohistochemistry - Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker (AB68428)

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Primary Antibodies

AB7291

Anti-alpha Tubulin antibody [DM1A] - Loading Control

BOND RX™ Validated

Western blot - Anti-alpha Tubulin antibody [DM1A] - Loading Control (AB7291)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Product promise

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