Losartan potassium, non-peptide angiotensin II AT1 receptor antagonist

Key facts

CAS number

124750-99-8

Purity

>99%

Form

Solid

form

Molecular weight

461 Da

Molecular formula

C₂₂H₂₂ClKN₆O

PubChem

11751549

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

Cozaar

Biological description

Selective non-peptide angiotensin II type 1 (AT1) receptor antagonist (Ki = 10 nM). Blocks classical actions of angiotensin II (ab120183). Displays antihypertensive action and downregulates TFG-β regulation. Active *in vivo*.

Canonical smiles

CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]

InChi

InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

InChiKey

OXCMYAYHXIHQOA-UHFFFAOYSA-N

IUPAC Name

potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol