MW 404.5 Da, Purity >98%. Potent, competitive HMG-CoA reductase inhibitor (Ki = 0.6 nM). Blood-brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo.
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- Cell reports 37:1100562021Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMadeleine Dorsch,Manuela Kowalczyk,Mélanie Planque,Geronimo Heilmann,Sebastian Urban,Philip Dujardin,Jan Forster,Kristina Ueffing,Silke Nothdurft,Sebastian Oeck,Annika Paul,Sven T Liffers,Farnusch Kaschani,Markus Kaiser,Alexander Schramm,Jens T Siveke,Monte M Winslow,Sarah-Maria Fendt,Perihan Nalbant,Barbara M GrünerPubMed 34818551
- Frontiers in oncology 11:6566872021Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChanjuan Zheng,Shichao Yan,Lu Lu,Hui Yao,Guangchun He,Sisi Chen,Ying Li,Xiaojun Peng,Zhongyi Cheng,Mi Wu,Qiuting Zhang,Guifei Li,Shujun Fu,Xiyun DengPubMed 34150623
- Scientific reports 11:87432021The antiviral effect of metformin on zika and dengue virus infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCarlos Noe Farfan-Morales,Carlos Daniel Cordero-Rivera,Juan Fidel Osuna-Ramos,Irma Eloisa Monroy-Muñoz,Luis Adrián De Jesús-González,José Esteban Muñoz-Medina,Arianna M Hurtado-Monzón,José Manuel Reyes-Ruiz,Rosa María Del ÁngelPubMed 33888740
- Molecular cell 75:252-266.e82019Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndres Canela,Yaakov Maman,Shar-Yin N Huang,Gordana Wutz,Wen Tang,Guido Zagnoli-Vieira,Elsa Callen,Nancy Wong,Amanda Day,Jan-Michael Peters,Keith W Caldecott,Yves Pommier,André NussenzweigPubMed 31202577
- Nature communications 8:19882017low neurotrophin receptor CD271 regulates phenotype switching in melanoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGaetana Restivo et. al.PubMed 29215016
- Journal of Cancer 8:1655-16642017Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYikun Peng et. al.PubMed 28775785
Key facts
- CAS number
- 75330-75-5
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 404.5 Da
- Molecular formula
- C24H36O5
- PubChem identifier
- 53232
- Nature
- Synthetic
Target data
Recommended products
MW 404.5 Da, Purity >98%. Potent, competitive HMG-CoA reductase inhibitor (Ki = 0.6 nM). Blood-brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo.
Key facts
- CAS number
- 75330-75-5
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 404.5 Da
- Molecular formula
- C24H36O5
- PubChem identifier
- 53232
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 50 mM.
- Biochemical name
- Lovastatin
- Biological description
Potent, competitive HMG-CoA reductase inhibitor (Ki = 0.6 nM). Blood-brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo.
- Canonical SMILES
- CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
- Isomeric SMILES
- CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
- InChI
- InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
- InChIKey
- PCZOHLXUXFIOCF-BXMDZJJMSA-N
- IUPAC name
- [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Lovastatin (Mevinolin), HMG-CoA reductase inhibitor (ab120614)
2D chemical structure image of ab120614, Lovastatin (Mevinolin), HMG-CoA reductase inhibitor
Functional Studies - Lovastatin (Mevinolin), HMG-CoA reductase inhibitor (ab120614)
ab87359 staining cyclin A in DU145 cells treated with lovastatin (ab120614), by ICC/IF. Decrease in cyclin A expression correlates with increased concentration of lovastatin, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120614 (lovastatin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab87359 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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