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AB142187

Loxoribine (RW-J-21757), Toll-like receptor 7 (TLR7) agonist

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MW 339.3 Da, Purity >97%. Toll-like receptor 7 (TLR7) agonist. Induces immune cell activation and cytokine production. Displays antitumor activity in vivo.

Key facts

CAS number

121288-39-9

Purity

>97%

Form

Solid

form

Molecular weight

339.3 Da

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>7</sub>N<sub>5</sub>O<sub>6</sub>

PubChem

60737

Nature

Synthetic

Solubility

Soluble in DMSO to 75 mM

Soluble in water to 25 mM

Biochemical name

CID 60737

Biological description

Toll-like receptor 7 (TLR7) agonist. Induces immune cell activation and cytokine production. Displays antitumor activity in vivo.

Canonical smiles

C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O

Isomeric smiles

C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

InChi

InChI=1S/C13H17N5O6/c1-2-3-17-6-9(15-12(14)16-10(6)22)18(13(17)23)11-8(21)7(20)5(4-19)24-11/h2,5,7-8,11,19-21H,1,3-4H2,(H3,14,15,16,22)/t5-,7-,8-,11-/m1/s1

InChiKey

VDCRFBBZFHHYGT-IOSLPCCCSA-N

IUPAC Name

2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-enyl-3H-purine-6,8-dione

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2003 Loxoribine. 2003-25 is the same size as the 25 mg size of ab142187.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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