MW 386.6 Da, Purity >98%. Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge *Luffariella* sp. Displays anti-inflammatory activity and active *in vivo*.
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- The Biochemical journal 446:79-872012Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShanshan Wang,Zhao Wang,Shengchen Lin,Weili Zheng,Rui Wang,Shikai Jin,Jinan Chen,Lihua Jin,Yong LiPubMed 22642567
- Skin pharmacology : the official journal of the Skin Pharmacology Society 8:300-81995Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesK B Glaser,M L Sung,D A Hartman,Y W Lock,J Bauer,T Walter,R P CarlsonPubMed 8688196
- Agents and actions 34:89-921991PAF and LTB4 biosynthesis in the human neutrophil: effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5-lipoxygenase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesK B Glaser,Y W Lock,J Y ChangPubMed 1665306
Key facts
- CAS number
111149-87-2
- Purity
> 98%
- Source
Luffariella sp.
- Molecular weight
386.6 Da
- Molecular formula
C25H38O3
- PubChem identifier
5387248
- Nature
Native
Target data
Recommended products
MW 386.6 Da, Purity >98%. Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge *Luffariella* sp. Displays anti-inflammatory activity and active *in vivo*.
Key facts
- CAS number
111149-87-2
- Purity
> 98%
- Source
Luffariella sp.
- Molecular weight
386.6 Da
- Molecular formula
C25H38O3
- PubChem identifier
5387248
- Nature
Native
- Solubility
Soluble in DMSO. Soluble in ethanol.
- Biochemical name
Luffariellolide
- Biological description
Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge *Luffariella* sp. Displays anti-inflammatory activity and active *in vivo*.
- Canonical SMILES
CC1=C(C(CCC1)(C)C)CCC(=CCCC(=CCCC2=CC(=O)OC2O)C)C
- Isomeric SMILES
CC1=C(C(CCC1)(C)C)CC/C(=C/CC/C(=C/CCC2=CC(=O)OC2O)/C)/C
- InChI
InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
- InChIKey
JPWPYTMXSXYUPG-QZPYEDBESA-N
- IUPAC name
3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
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1 product image
Chemical Structure - Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha (ab141759)
2D chemical structure image of ab141759, Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha
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