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MW 386.6 Da, Purity >98%. Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge *Luffariella* sp. Displays anti-inflammatory activity and active *in vivo*.

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Images

Chemical Structure - Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha (AB141759), expandable thumbnail

Key facts

CAS number
111149-87-2
Purity
> 98%
Source
Luffariella sp.
Molecular weight
386.6 Da
Molecular formula
C25H38O3
PubChem identifier
5387248
Nature
Native

Target data

Recommended products

MW 386.6 Da, Purity >98%. Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge *Luffariella* sp. Displays anti-inflammatory activity and active *in vivo*.

Key facts

Purity
> 98%
Source
Luffariella sp.
PubChem identifier
5387248
Solubility

Soluble in DMSO.

Soluble in ethanol.

Biochemical name
Luffariellolide
Biological description

Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge *Luffariella* sp. Displays anti-inflammatory activity and active *in vivo*.

Canonical SMILES
CC1=C(C(CCC1)(C)C)CCC(=CCCC(=CCCC2=CC(=O)OC2O)C)C
Isomeric SMILES
CC1=C(C(CCC1)(C)C)CC/C(=C/CC/C(=C/CCC2=CC(=O)OC2O)/C)/C
InChI
InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
InChIKey
JPWPYTMXSXYUPG-QZPYEDBESA-N
IUPAC name
3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions

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1 product image

  • Chemical Structure - Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha (ab141759), expandable thumbnail

    Chemical Structure - Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha (ab141759)

    2D chemical structure image of ab141759, Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha

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Product protocols

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