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AB141759

Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha

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MW 386.6 Da, Purity >98%. Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge *Luffariella* sp. Displays anti-inflammatory activity and active *in vivo*.
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Chemical Structure - Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha (AB141759)
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Chemical Structure - Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha (AB141759)

2D chemical structure image of ab141759, Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha

Key facts

CAS number

111149-87-2

Purity

>98%

Source

Luffariella sp.

Molecular weight

386.6 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>3</sub><sub>8</sub>O<sub>3</sub>

PubChem

5387248

Nature

Native

Solubility

Soluble in DMSO

Soluble in ethanol

Biochemical name

Luffariellolide

Biological description

Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge *Luffariella* sp. Displays anti-inflammatory activity and active *in vivo*.

Canonical smiles

CC1=C(C(CCC1)(C)C)CCC(=CCCC(=CCCC2=CC(=O)OC2O)C)C

Isomeric smiles

CC1=C(C(CCC1)(C)C)CC/C(=C/CC/C(=C/CCC2=CC(=O)OC2O)/C)/C

InChi

InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+

InChiKey

JPWPYTMXSXYUPG-QZPYEDBESA-N

IUPAC Name

3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one

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Complementary Products

Biochemicals

AB141758

RHC-80267, diacylglycerol lipase inhibitor

Chemical Structure - RHC-80267, diacylglycerol lipase inhibitor (AB141758)

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Biochemicals

AB141397

C75, fatty acid synthase (FAS) inhibitor

Chemical Structure - C75, fatty acid synthase (FAS) inhibitor (AB141397)

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Biochemicals

AB141578

TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor.

Chemical Structure - TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor. (AB141578)

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Biochemicals

AB141760

ONO-RS-082, phospholipase A2 (PLA2) inhibitor

Chemical Structure - ONO-RS-082, phospholipase A2 (PLA2) inhibitor (AB141760)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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