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AB120546

LY 272015 hydrochloride, 5-HT2B antagonist

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MW 372.9 Da, Purity >98%. Highly potent, selective 5-HT2B receptor antagonist (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors, respectively). Displays antihypertensive activity *in vivo*.
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Chemical Structure - LY 272015 hydrochloride, 5-HT2B antagonist (AB120546)
  • Chemical Structure

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Chemical Structure - LY 272015 hydrochloride, 5-HT2B antagonist (AB120546)

2D chemical structure image of ab120546, LY 272015 hydrochloride, 5-HT2B antagonist

Key facts

CAS number

172895-15-7

Purity

>98%

Form

Solid

form

Molecular weight

372.9 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>5</sub>ClN<sub>2</sub>O<sub>2</sub>

PubChem

9929423

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

LY 272015 Hydrochloride

Biological description

Highly potent, selective 5-HT2B receptor antagonist (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors, respectively). Displays antihypertensive activity *in vivo*.

Canonical smiles

CC1=CC2=C(C=C1)NC3=C2CCNC3CC4=CC(=C(C=C4)OC)OC.Cl

InChi

InChI=1S/C21H24N2O2.ClH/c1-13-4-6-17-16(10-13)15-8-9-22-18(21(15)23-17)11-14-5-7-19(24-2)20(12-14)25-3;/h4-7,10,12,18,22-23H,8-9,11H2,1-3H3;1H

InChiKey

BKAZOTIBKRWLQA-UHFFFAOYSA-N

IUPAC Name

1-[(3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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