LY 341495, Group II antagonist

Key facts

CAS number

201943-63-7

Purity

>98%

Form

Solid

form

Molecular weight

353.4 Da

Molecular formula

C₂₀H₁₉NO₅

PubChem

9819927

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Soluble in 1.2 eq. NaOH to 100 mM

Biochemical name

2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine

Biological description

Water-soluble and very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Disodium salt of LY 341495 (ab120199) which displays K_d values of 1.67 (human mGlu₂), 0.75 (mGlu₃), 31.6 (mGlu₆), 72.7 (mGlu_7a) and 14 (human mGlu_8a receptors) nM. LY 341495 displays IC₅₀ values of 7.8, 8.2 and 22 μM for mGlu_1a, mGlu_5a and mGlu₄ receptors, respectively. It is readily brain penetrant and active in vivo.

Also available in simple stock solutions (ab144500) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical smiles

C1C(C1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O

Isomeric smiles

C1[C@@H]([C@H]1[C@@](CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O

InChi

InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1

InChiKey

VLZBRVJVCCNPRJ-KPHUOKFYSA-N

IUPAC Name

(1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid