AB120592
LY 344864 hydrochloride, 5-HT1F agonist
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(1 Publication)
MW 387.88 g/mol, Purity >98%. Selective, potent, full 5-HT1F agonist (EC50 = 3 nM). Selectivity is 80-fold greater than for other 5-HT receptor subtypes, Ki values are 0.53 (5-HT1A), 0.549 (5-HT1B), 0.575 (5-HT1D), 1.415 (5-HT1E), 3.935 (5-HT2A), 1.695 (5-HT2B), 3.499 (5-HT2C) and 4.851 (5-HT7). Able to reduce central sensitization and dural inflammation in vivo.
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- Chemical Structure
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Chemical Structure - LY 344864 hydrochloride, 5-HT1F agonist (AB120592)
2D chemical structure image of ab120592, LY 344864 hydrochloride, 5-HT1F agonist
Properties and storage information
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
Publications (1)
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EMBO reports 17:585-600 PubMed26929027
2016
A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.
Applications
Unspecified application
Species
Unspecified reactive species
Kalina K Stantcheva,Loredana Iovino,Rahul Dhandapani,Concepcion Martinez,Laura Castaldi,Linda Nocchi,Emerald Perlas,Carla Portulano,Martina Pesaresi,Kalyanee S Shirlekar,Fernanda de Castro Reis,Triantafillos Paparountas,Daniel Bilbao,Paul A Heppenstall
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