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MW 387.88 g/mol, Purity >98%.

Selective, potent, full 5-HT1F agonist (EC50 = 3 nM). Selectivity is 80-fold greater than for other 5-HT receptor subtypes, Ki values are 0.53 (5-HT1A), 0.549 (5-HT1B), 0.575 (5-HT1D), 1.415 (5-HT1E), 3.935 (5-HT2A), 1.695 (5-HT2B), 3.499 (5-HT2C) and 4.851 (5-HT7). Able to reduce central sensitization and dural inflammation in vivo.

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Images

Chemical Structure - LY 344864 hydrochloride, 5-HT1F agonist (AB120592), expandable thumbnail

Publications

Key facts

CAS number
186544-26-3
Purity
> 98%
Form
Solid
Molecular weight
387.88 g/mol
Nature
Synthetic

Target data

Recommended products

MW 387.88 g/mol, Purity >98%.

Selective, potent, full 5-HT1F agonist (EC50 = 3 nM). Selectivity is 80-fold greater than for other 5-HT receptor subtypes, Ki values are 0.53 (5-HT1A), 0.549 (5-HT1B), 0.575 (5-HT1D), 1.415 (5-HT1E), 3.935 (5-HT2A), 1.695 (5-HT2B), 3.499 (5-HT2C) and 4.851 (5-HT7). Able to reduce central sensitization and dural inflammation in vivo.

Key facts

Purity
> 98%
Solubility

Soluble in DMSO to 100 mM.

Soluble in water to 5 mM.

Biological description

Selective, potent, full 5-HT1F agonist (EC50 = 3 nM). Selectivity is 80-fold greater than for other 5-HT receptor subtypes, Ki values are 0.53 (5-HT1A), 0.549 (5-HT1B), 0.575 (5-HT1D), 1.415 (5-HT1E), 3.935 (5-HT2A), 1.695 (5-HT2B), 3.499 (5-HT2C) and 4.851 (5-HT7). Able to reduce central sensitization and dural inflammation in vivo.

IUPAC name
N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - LY 344864 hydrochloride, 5-HT1F agonist (ab120592), expandable thumbnail

    Chemical Structure - LY 344864 hydrochloride, 5-HT1F agonist (ab120592)

    2D chemical structure image of ab120592, LY 344864 hydrochloride, 5-HT1F agonist

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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