JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120173

LY 354740, Group II mGlu agonist

Be the first to review this product! Submit a review

|

(1 Publication)

MW 185.18 Da, Purity >98%. Highly potent and selective agonist at mGlu2 and mGlu3 receptors (EC50 values are 5.1 and 24.3 nM, respectively). Displays no agonist or antagonist activity at mGlu1a, mGlu5a, mGlu4 or mGlu7 receptors at concentrations up to 100 μM. Orally and systemically active. Anxiolytic and antiaddictive effects in vivo.

View Alternative Names

AMPA-selective glutamate receptor 2, GLUR, GPRC1B, GRM2_HUMAN, GluR-2, GluR-B, Glutamate metabotropic receptor 2, Glutamate receptor homolog, Glutamate receptor metabotropic 2, MGLUR2, Metabotropic glutamate receptor 2, OTTHUMP00000210984, OTTHUMP00000210986, Smp_128940, mGlu2

1 Images
Chemical Structure - LY 354740, Group II mGlu agonist (AB120173)
  • Chemical Structure

Lab

Chemical Structure - LY 354740, Group II mGlu agonist (AB120173)

2D chemical structure image of ab120173, LY 354740, Group II mGlu agonist

Key facts

CAS number

176199-48-7

Purity

>98%

Form

Solid

form

Molecular weight

185.18 Da

Molecular formula

C<sub>8</sub>H<sub>1</sub><sub>1</sub>NO<sub>4</sub>

PubChem

213056

Nature

Synthetic

Solubility

Soluble in 1 eq. NaOH to 100 mM

Biochemical name

(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Biological description

Highly potent and selective agonist at mGlu2 and mGlu3 receptors (EC50 values are 5.1 and 24.3 nM, respectively). Displays no agonist or antagonist activity at mGlu1a, mGlu5a, mGlu4 or mGlu7 receptors at concentrations up to 100 μM. Orally and systemically active. Anxiolytic and antiaddictive effects in vivo.

Canonical smiles

C1CC(C2C1C2C(=O)O)(C(=O)O)N

Isomeric smiles

C1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N

InChi

InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1

InChiKey

VTAARTQTOOYTES-RGDLXGNYSA-N

IUPAC Name

(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neuroscience 250:189-200 PubMed23867766

2013

Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740.

Applications

Unspecified application

Species

Unspecified reactive species

C Procaccini,M Maksimovic,T Aitta-Aho,E R Korpi,A-M Linden
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

  • 0
  • 0
Biochemicals

AB120007

(S)-3,5-DHPG, group I mGlu agonist

Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)

  • 0
  • 0
Biochemicals

AB120042

SR95531 (Gabazine), GABAA antagonist

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

  • 0
  • 0
Biochemicals

AB120067

LY 367385, mGlu1a antagonist

Chemical Structure - LY 367385, mGlu1a antagonist (AB120067)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com