MW 209.2 Da, Purity >99%. Potent, selective mGlu1a antagonist. Neuroprotective and anticonvulsant *in vivo*.
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12 Publications for All applications
- The Journal of neuroscience : the official journal of the Society for Neuroscience 42:6211-62202022Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNicole F Wong,Matthew A Xu-FriedmanPubMed 35790402
- Neuron 98:935-944.e52018Astroglial CB Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLaurie M Robin et. al.PubMed 29779943
- Nature communications 7:135712016Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndrew G Eng et. al.PubMed 27886171
- Scientific reports 6:284542016Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichelangelo Colavita et. al.PubMed 27345695
- Frontiers in cellular neuroscience 9:3452015Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLuca Bragina et. al.PubMed 26388733
- The Journal of neuroscience : the official journal of the Society for Neuroscience 33:13743-572013CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesThomas J Younts,Vivien Chevaleyre,Pablo E CastilloPubMed 23966696
- Journal of neurophysiology 110:470-802013Thalamic microcircuits: presynaptic dendrites form two feedforward inhibitory pathways in thalamus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShane R Crandall et. al.PubMed 23615551
- Neuropharmacology 63:486-932012mGlu1α-dependent recruitment of excitatory GABAergic input to neocortical Cajal-Retzius cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKathleen E Cosgrove et. al.PubMed 22579657
- Nature neuroscience 15:746-532012Astrocyte signaling controls spike timing-dependent depression at neocortical synapses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRogier Min et. al.PubMed 22446881
- The Journal of neuroscience : the official journal of the Society for Neuroscience 31:17383-912011Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHenning Fenselau,Bernhard Heinke,Jürgen SandkühlerPubMed 22131400
Key facts
- CAS number
- 198419-91-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 209.2 Da
- Molecular formula
- C10H11NO4
- PubChem identifier
- 5311261
- Nature
- Synthetic
Alternative names
GLUR, Smp_128940
Recommended products
MW 209.2 Da, Purity >99%. Potent, selective mGlu1a antagonist. Neuroprotective and anticonvulsant *in vivo*.
Key facts
- CAS number
- 198419-91-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 209.2 Da
- Molecular formula
- C10H11NO4
- PubChem identifier
- 5311261
- Nature
- Synthetic
- Solubility
Soluble in 1.1 eq. NaOH to 100 mM.
- Biochemical name
- 4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid
- Biological description
Potent, selective mGlu1a antagonist. Neuroprotective and anticonvulsant *in vivo*.
- Canonical SMILES
- CC1=C(C=CC(=C1)C(=O)O)C(C(=O)O)N
- Isomeric SMILES
- CC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N
- InChI
- InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
- InChIKey
- SGIKDIUCJAUSRD-QMMMGPOBSA-N
- IUPAC name
- 4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - LY 367385, mGlu1a antagonist (ab120067)
2D chemical structure image of ab120067, LY 367385, mGlu1a antagonist
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