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AB120067

LY 367385, mGlu1a antagonist

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(12 Publications)

MW 209.2 Da, Purity >99%. Potent, selective mGlu1a antagonist. Neuroprotective and anticonvulsant *in vivo*. Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

GLUR, Smp_128940

1 Images
Chemical Structure - LY 367385, mGlu1a antagonist (AB120067)
  • Chemical Structure

Lab

Chemical Structure - LY 367385, mGlu1a antagonist (AB120067)

2D chemical structure image of ab120067, LY 367385, mGlu1a antagonist

Key facts

CAS number

198419-91-9

Purity

>99%

Form

Solid

form

Molecular weight

209.2 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>1</sub><sub>1</sub>NO<sub>4</sub>

PubChem

5311261

Nature

Synthetic

Solubility

Soluble in 1.1 eq. NaOH to 100 mM

Biochemical name

4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid

Biological description

Potent, selective mGlu1a antagonist. Neuroprotective and anticonvulsant *in vivo*.

Canonical smiles

CC1=C(C=CC(=C1)C(=O)O)C(C(=O)O)N

Isomeric smiles

CC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N

InChi

InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1

InChiKey

SGIKDIUCJAUSRD-QMMMGPOBSA-N

IUPAC Name

4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (12)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:6211-6220 PubMed35790402

2022

Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole F Wong,Matthew A Xu-Friedman

Neuron 98:935-944.e5 PubMed29779943

2018

Astroglial CB Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory.

Applications

Unspecified application

Species

Unspecified reactive species

Laurie M Robin,José F Oliveira da Cruz,Valentin C Langlais,Mario Martin-Fernandez,Mathilde Metna-Laurent,Arnau Busquets-Garcia,Luigi Bellocchio,Edgar Soria-Gomez,Thomas Papouin,Marjorie Varilh,Mark W Sherwood,Ilaria Belluomo,Georgina Balcells,Isabelle Matias,Barbara Bosier,Filippo Drago,Ann Van Eeckhaut,Ilse Smolders,Francois Georges,Alfonso Araque,Aude Panatier,Stéphane H R Oliet,Giovanni Marsicano

Nature communications 7:13571 PubMed27886171

2016

Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew G Eng,Daniel A Kelver,Tristan P Hedrick,Geoffrey T Swanson

Scientific reports 6:28454 PubMed27345695

2016

Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Michelangelo Colavita,Geoffrey Terral,Clement E Lemercier,Filippo Drago,Giovanni Marsicano,Federico Massa

Frontiers in cellular neuroscience 9:345 PubMed26388733

2015

Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.

Applications

Unspecified application

Species

Unspecified reactive species

Luca Bragina,Tiziana Bonifacino,Silvia Bassi,Marco Milanese,Giambattista Bonanno,Fiorenzo Conti

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:13743-57 PubMed23966696

2013

CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas J Younts,Vivien Chevaleyre,Pablo E Castillo

Journal of neurophysiology 110:470-80 PubMed23615551

2013

Thalamic microcircuits: presynaptic dendrites form two feedforward inhibitory pathways in thalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Shane R Crandall,Charles L Cox

Neuropharmacology 63:486-93 PubMed22579657

2012

mGlu1α-dependent recruitment of excitatory GABAergic input to neocortical Cajal-Retzius cells.

Applications

Unspecified application

Species

Unspecified reactive species

Kathleen E Cosgrove,Gianmaria Maccaferri

Nature neuroscience 15:746-53 PubMed22446881

2012

Astrocyte signaling controls spike timing-dependent depression at neocortical synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Rogier Min,Thomas Nevian

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:17383-91 PubMed22131400

2011

Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Henning Fenselau,Bernhard Heinke,Jürgen Sandkühler
View all publications
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