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AB120196

LY 379268, Group II mGlu agonist

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(8 Publications)

MW 187.15 Da, Purity >99%. Highly potent and systemically active mGlu2 and mGlu3 agonist. EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays >80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.

View Alternative Names

AMPA-selective glutamate receptor 2, GLUR, GPRC1B, GPRC1C, GRM2_HUMAN, GRM3_HUMAN, GluR-2, GluR-3, GluR-B, Glutamate metabotropic receptor 2, Glutamate metabotropic receptor 3, Glutamate receptor homolog, Glutamate receptor metabotropic 2, Glutamate receptor metabotropic 3, MGLUR2, MGLUR3, MGlu3, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 3, OTTHUMP00000210984, OTTHUMP00000210986, Smp_128940, mGlu2

1 Images
Chemical Structure - LY 379268, Group II mGlu agonist (AB120196)
  • Chemical Structure

Lab

Chemical Structure - LY 379268, Group II mGlu agonist (AB120196)

2D chemical structure image of ab120196, LY 379268, Group II mGlu agonist

Key facts

CAS number

191471-52-0

Purity

>99%

Form

Solid

form

Molecular weight

187.15 Da

Molecular formula

C<sub>7</sub>H<sub>9</sub>NO<sub>5</sub>

PubChem

10197984

Nature

Synthetic

Solubility

Soluble in water to 25 mM (with heating)

Biochemical name

(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid

Biological description

Highly potent and systemically active mGlu2 and mGlu3 agonist. EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays >80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.

Canonical smiles

C1C(C2C(C2O1)C(=O)O)(C(=O)O)N

Isomeric smiles

C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N

InChi

InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1

InChiKey

YASVRZWVUGJELU-MDASVERJSA-N

IUPAC Name

(1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid

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Complementary Products

Biochemicals

AB120440

NECA, adenosine agonist

Chemical Structure - NECA, adenosine agonist (AB120440)

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Biochemicals

AB120019

Clozapine, Atypical antipsychotic

Chemical Structure - Clozapine, Atypical antipsychotic (AB120019)

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Biochemicals

AB141633

24(S),25-Epoxycholesterol, Endogenous cholesterol metabolite

Chemical Structure - 24(S),25-Epoxycholesterol, Endogenous cholesterol metabolite (AB141633)

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Biochemicals

AB285422

Sulfo-LC-SPDP

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Biology of reproduction 107:916-927 PubMed35746896

2022

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Špirková,Veronika Kovaříková,Zuzana Šefčíková,Jozef Pisko,Martina Kšiňanová,Juraj Koppel,Dušan Fabian,Štefan Čikoš

Neural regeneration research 16:727-733 PubMed33063735

2020

Abnormal Glu/mGluR/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Liu,Yuan-Shan Han,Lin Liu,Lin Tang,Hui Yang,Pan Meng,Hong-Qing Zhao,Yu-Hong Wang

Frontiers in cellular neuroscience 9:345 PubMed26388733

2015

Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.

Applications

Unspecified application

Species

Unspecified reactive species

Luca Bragina,Tiziana Bonifacino,Silvia Bassi,Marco Milanese,Giambattista Bonanno,Fiorenzo Conti

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:79-94 PubMed24381270

2014

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.

Applications

Unspecified application

Species

Unspecified reactive species

Shen Yin,Meredith J Noetzel,Kari A Johnson,Rocio Zamorano,Nidhi Jalan-Sakrikar,Karen J Gregory,P Jeffrey Conn,Colleen M Niswender

Behavioural brain research 253:9-16 PubMed23827202

2013

Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning.

Applications

Unspecified application

Species

Unspecified reactive species

D Klakotskaia,A K Ramsey,S W Fowler,P Serfozo,A Simonyi,T R Schachtman

Neuropsychopharmacology : official publication of 38:2220-30 PubMed23670591

2013

Upregulation of mGlu2 receptors via NF-κB p65 acetylation is involved in the Proneurogenic and antidepressant effects of acetyl-L-carnitine.

Applications

Unspecified application

Species

Unspecified reactive species

Bruna Cuccurazzu,Valeria Bortolotto,Maria Maddalena Valente,Federica Ubezio,Aleardo Koverech,Pier Luigi Canonico,Mariagrazia Grilli

Neuropsychopharmacology : official publication of 36:1599-607 PubMed21451497

2011

mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Heather B Gosnell,Yuval Silberman,Brad A Grueter,Robert M Duvoisin,Jacob Raber,Danny G Winder

The Journal of pharmacology and experimental thera 330:227-35 PubMed19357321

2009

Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Daniella Rylander,Alessandra Recchia,Flora Mela,Andrzej Dekundy,Wojciech Danysz,M Angela Cenci
View all publications
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