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AB120201

LY 456236, mGlu1 non competitive antagonist

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MW 317.77 Da, Purity >99%. Selective non-competitive antagonist at the mGlu1 receptor. Inhibits agonist induced phosphoinositide hydrolysis *in vitro* (IC50 = 140 nM) and *in vivo* following systemic administration.

View Alternative Names

GLUR, Smp_128940

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Chemical Structure - LY 456236, mGlu1 non competitive antagonist (AB120201)
  • Chemical Structure

Lab

Chemical Structure - LY 456236, mGlu1 non competitive antagonist (AB120201)

2D chemical structure image of ab120201, LY 456236, mGlu1 non competitive antagonist

Key facts

CAS number

338738-57-1

Purity

>99%

Form

Solid

form

Molecular weight

317.77 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>6</sub>ClN<sub>3</sub>O<sub>2</sub>

PubChem

9926998

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM (with warming)

Biochemical name

LY 456236 Hydrochloride

Biological description

Selective non-competitive antagonist at the mGlu1 receptor. Inhibits agonist induced phosphoinositide hydrolysis *in vitro* (IC50 = 140 nM) and *in vivo* following systemic administration.

Canonical smiles

COC1=CC=C(C=C1)NC2=NC=NC3=C2C=C(C=C3)OC.Cl

InChi

InChI=1S/C16H15N3O2.ClH/c1-20-12-5-3-11(4-6-12)19-16-14-9-13(21-2)7-8-15(14)17-10-18-16;/h3-10H,1-2H3,(H,17,18,19);1H

InChiKey

AVKFOWUSTVWZQN-UHFFFAOYSA-N

IUPAC Name

6-methoxy-N-(4-methoxyphenyl)quinazolin-4-amine;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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