LY2874455, FGF/FGFR inhibitor

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(2 Publications)

MW 444.3 Da, Purity >98%. Potent FGF/FGFR inhibitor. Inhibits in vitro autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 with similar inhibition potency for all four FGFRs (IC₅₀ < 6.4 nM). Exhibits a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice.

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AS, BFGFR, Basic fibroblast growth factor receptor 1, Beta-interferon, CD309, CD309 antigen, CD331, CEK, EC 2.7.10.1, FGFBR, FGFR1/PLAG1 fusion, FGFR1_HUMAN, FLG, FLK-1, FLK1, mouse, homolog of, FLT-2, Fetal liver kinase 1, Fibroblast interferon, Fms-like gene, Fms-like tyrosine kinase 2, HBGFR, HH2, HLA B protein, HLA class I histocompatibility antigen, B alpha chain, HLA-B histocompatibility type, HRTFDS, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, KAL2, KRD1, Kdr, Kinase insert domain receptor, Kinase insert domain receptor (a type III receptor tyrosine kinase), Ly73, Lymphocyte antigen, MGC96956, MHC Class I HLA heavy chain, MHC HLA-B cell surface glycoprotein, MHC HLA-B transmembrane glycoprotein, MHC class I antigen GN00104, MHC class I antigen HLA-B heavy chain, MHC class I antigen SHCHA, N-SAM, OGD, Protein-tyrosine kinase receptor flk-1, Proto-oncogene c-Fgr, SPDA1, Tyrosine kinase growth factor receptor, VEGFR, VEGFR-2, VGFR2_HUMAN, Vascular endothelial growth factor receptor 2, bFGF-R-1, fibroblast growth factor receptor 1, fms-related tyrosine kinase 2, heparin-binding growth factor receptor, hydroxyaryl-protein kinase, leukocyte antigen class I-B, major histocompatibility complex, class I, B, soluble VEGFR2