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MW 550.6 Da, Purity >96%. Potent, selective, competitive cell-permeable Ras farnesyltransferase (Ki = 1.2 μM) inhibitor. IκB kinase inhibitor. Antibiotic agent. Induces apoptosis. Shows antitumor effects in vivo. .
Alternative names=IMD42, MGC129539, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, TOR
- CAS number
52665-74-4
- Purity
> 96%
- Form
Solid
- Source
Streptomyces parvulus
- Molecular weight
550.6 Da
- Molecular formula
C31H38N2O7
- PubChem identifier
6438330
- Nature
Native
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MW 550.6 Da, Purity >96%. Potent, selective, competitive cell-permeable Ras farnesyltransferase (Ki = 1.2 μM) inhibitor. IκB kinase inhibitor. Antibiotic agent. Induces apoptosis. Shows antitumor effects in vivo. .
Alternative names=IMD42, MGC129539, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, TOR
Key facts
- CAS number
52665-74-4
- Purity
> 96%
- Form
Solid
- Source
Streptomyces parvulus
- Molecular weight
550.6 Da
- Molecular formula
C31H38N2O7
- PubChem identifier
6438330
- Nature
Native
- Biochemical name
Manumycin A
- Biological description
Potent, selective, competitive cell-permeable Ras farnesyltransferase (Ki = 1.2 μM) inhibitor. IκB kinase inhibitor. Antibiotic agent. Induces apoptosis. Shows antitumor effects in vivo.
- Canonical SMILES
CCCCC(C)C=C(C)C=C(C)C(=O)NC1=CC(C2C(C1=O)O2)(C=CC=CC=CC(=O)NC3=C(CCC3=O)O)O
- Isomeric SMILES
CCCC[C@@H](C)/C=C(\C)/C=C(\C)/C(=O)NC1=C[C@]([C@H]2[C@@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O
- InChI
InChI=1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1
- InChIKey
TWWQHCKLTXDWBD-MVTGTTCWSA-N
- IUPAC name
(2E,4E,6R)-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
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