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AB144297

Manumycin A, Ras farnesyltransferase inhibitor

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MW 550.6 Da, Purity >96%. Potent, selective, competitive cell-permeable Ras farnesyltransferase (Ki = 1.2 μM) inhibitor. IκB kinase inhibitor. Antibiotic agent. Induces apoptosis. Shows antitumor effects in vivo. .
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Chemical Structure - Manumycin A, Ras farnesyltransferase inhibitor (AB144297)
  • Chemical Structure

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Chemical Structure - Manumycin A, Ras farnesyltransferase inhibitor (AB144297)

2D chemical structure image of ab144297, Manumycin A, Ras farnesyltransferase inhibitor

Key facts

CAS number

52665-74-4

Purity

>96%

Form

Solid

form

Source

Streptomyces parvulus

Molecular weight

550.6 Da

Molecular formula

C<sub>3</sub><sub>1</sub>H<sub>3</sub><sub>8</sub>N<sub>2</sub>O<sub>7</sub>

PubChem

6438330

Nature

Native

Solubility

Soluble in DMSO to 10 mM

Biochemical name

Manumycin A

Biological description

Potent, selective, competitive cell-permeable Ras farnesyltransferase (Ki = 1.2 μM) inhibitor. IκB kinase inhibitor. Antibiotic agent. Induces apoptosis. Shows antitumor effects in vivo.

Canonical smiles

CCCCC(C)C=C(C)C=C(C)C(=O)NC1=CC(C2C(C1=O)O2)(C=CC=CC=CC(=O)NC3=C(CCC3=O)O)O

Isomeric smiles

CCCC[C@@H](C)/C=C(\C)/C=C(\C)/C(=O)NC1=C[C@]([C@H]2[C@@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O

InChi

InChI=1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1

InChiKey

TWWQHCKLTXDWBD-MVTGTTCWSA-N

IUPAC Name

(2E,4E,6R)-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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