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MW 282.34 g/mol, Purity >99%. Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c. In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice.

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Publications

Key facts

CAS number
1625629-51-7
Purity
> 99%
Form
Solid
Molecular weight
282.34 g/mol
Molecular formula
C17H18N2O2
Nature
Synthetic

Target data

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MW 282.34 g/mol, Purity >99%. Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c. In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice.

Key facts

Purity
> 99%
Solubility

Soluble in DMSO to 100 mM.

Biological description

Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c. In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice.

Isomeric SMILES
CN(C)C1CCC(/C=C/C=C/C=C(/C#N)C(=O)OC)CC1
InChI
InChI=1S/C17H18N2O2/c1-19(2)16-11-9-14(10-12-16)7-5-4-6-8-15(13-18)17(20)21-3/h4-12H,1-3H3/b6-4+,7-5+,15-8-
IUPAC name
methyl (2Z,4E,6E)-2-cyano-7-[4-(dimethylamino)]hepta-2,4,6-trienoate

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

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