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AB216983

MCAAD-3, Near-infrared probe for imaging of amyloid plaques

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(2 Publications)

MW 282.34 g/mol, Purity >99%. Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c. In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice.

Key facts

CAS number

1625629-51-7

Purity

>99%

Form

Solid

form

Molecular weight

282.34 g/mol

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>8</sub>N<sub>2</sub>O<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c. In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice.

Isomeric smiles

CN(C)C1CCC(/C=C/C=C/C=C(/C#N)C(=O)OC)CC1

InChi

InChI=1S/C17H18N2O2/c1-19(2)16-11-9-14(10-12-16)7-5-4-6-8-15(13-18)17(20)21-3/h4-12H,1-3H3/b6-4+,7-5+,15-8-

IUPAC Name

methyl (2Z,4E,6E)-2-cyano-7-[4-(dimethylamino)]hepta-2,4,6-trienoate

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Complementary Products

Biochemicals

AB141775

CRANAD-2, Near-infrared Amyloid-beta fluorescent probe

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  • 0
Biochemicals

AB120301

beta-Amyloid Peptide (1-42) (human)

Chemical Structure - beta-Amyloid Peptide (1-42) (human) (AB120301)

  • 5
  • 1
Biochemicals

AB142818

Methoxy-X04, amyloid beta fluorescent marker

Chemical Structure - Methoxy-X04, amyloid beta fluorescent marker (AB142818)

  • 0
  • 0
Primary Antibodies

AB32136

Anti-Amyloid Precursor Protein antibody [Y188]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amyloid Precursor Protein antibody [Y188] (AB32136)

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  • 9
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in neuroscience 18:1325287 PubMed38406587

2024

The effect of human PBMCs immobilization on their Аβ42 aggregates-dependent proinflammatory state on a cellular model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Kateryna Kot,Yurii Kot,Rustam Kurbanov,Hanna Andriiash,Olena Tigunova,Yaroslav Blume,Sergiy Shulga

Acta neuropathologica communications 10:153 PubMed36307888

2022

Dual-probe fluorescence spectroscopy for sensitive quantitation of Alzheimer's amyloid pathology.

Applications

Unspecified application

Species

Unspecified reactive species

Anastasiia A Stepanchuk,Megan L Morgan,Jeffrey T Joseph,Peter K Stys
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