MW 382.5 Da, Purity >95%. Potent and selective cell-permeable calpain and cathepsin B inhibitor (IC50 = 11 nM, calpain, Ki values are 10 and 25 nM for calpain and cathepsin B respectively). Shows neuroprotective effects in vivo. Blood-brain barrier permeable.
Images
Publications
Filter by
- Oncology reports 41:3424-34342019Overexpression of calpain‑1 predicts poor outcome in patients with colorectal cancer and promotes tumor cell progression associated with downregulation of FLNA.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChangzhao Xu et. al.PubMed 31002357
- Frontiers in molecular neuroscience 11:2872018M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi Wan,Liang Ren,Lulan Chen,Guoxiang Wang,Xu Liu,Benjamin H Wang,Yun WangPubMed 30186110
Key facts
- CAS number
- 88191-84-8
- Purity
- > 95%
- Molecular weight
- 382.5 Da
- Molecular formula
- C22H26N2O4
- PubChem identifier
- 9907994
- Nature
- Synthetic
Target data
Recommended products
MW 382.5 Da, Purity >95%. Potent and selective cell-permeable calpain and cathepsin B inhibitor (IC50 = 11 nM, calpain, Ki values are 10 and 25 nM for calpain and cathepsin B respectively). Shows neuroprotective effects in vivo. Blood-brain barrier permeable.
Key facts
- CAS number
- 88191-84-8
- Purity
- > 95%
- Molecular weight
- 382.5 Da
- Molecular formula
- C22H26N2O4
- PubChem identifier
- 9907994
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- Z-Val-Phe-CHO
- Biological description
Potent and selective cell-permeable calpain and cathepsin B inhibitor (IC50 = 11 nM, calpain, Ki values are 10 and 25 nM for calpain and cathepsin B respectively). Shows neuroprotective effects in vivo. Blood-brain barrier permeable.
- Canonical SMILES
- CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
- InChI
- InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)
- InChIKey
- NGBKFLTYGSREKK-UHFFFAOYSA-N
- IUPAC name
- benzyl N-[3-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]butan-2-yl]carbamate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 2195 MDL 28170. 2195-50 is the same size as the 50 mg size of ab145601.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Chemical Structure - MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor (ab145601)
2D chemical structure image of ab145601, MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com