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AB145601

MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor

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(3 Publications)

MW 382.5 Da, Purity >95%. Potent and selective cell-permeable calpain and cathepsin B inhibitor (IC50 = 11 nM, calpain, Ki values are 10 and 25 nM for calpain and cathepsin B respectively). Shows neuroprotective effects in vivo. Blood-brain barrier permeable.
1 Images
Chemical Structure - MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor (AB145601)
  • Chemical Structure

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Chemical Structure - MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor (AB145601)

2D chemical structure image of ab145601, MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor

Key facts

CAS number

88191-84-8

Purity

>95%

Molecular weight

382.5 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>6</sub>N<sub>2</sub>O<sub>4</sub>

PubChem

9907994

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Z-Val-Phe-CHO

Biological description

Potent and selective cell-permeable calpain and cathepsin B inhibitor (IC50 = 11 nM, calpain, Ki values are 10 and 25 nM for calpain and cathepsin B respectively). Shows neuroprotective effects in vivo. Blood-brain barrier permeable.

Canonical smiles

CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2

InChi

InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)

InChiKey

NGBKFLTYGSREKK-UHFFFAOYSA-N

IUPAC Name

benzyl N-[3-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]butan-2-yl]carbamate

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2195 MDL 28170. 2195-50 is the same size as the 50 mg size of ab145601.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

mBio 15:e0288023 PubMed38349129

2024

Lyssavirus M protein degrades neuronal microtubules by reprogramming mitochondrial metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Yueming Yuan,An Fang,Haoran Wang,Caiqian Wang,Baokun Sui,Jianqing Zhao,Zhen F Fu,Ming Zhou,Ling Zhao

Oncology reports 41:3424-3434 PubMed31002357

2019

Overexpression of calpain‑1 predicts poor outcome in patients with colorectal cancer and promotes tumor cell progression associated with downregulation of FLNA.

Applications

Unspecified application

Species

Unspecified reactive species

Changzhao Xu,Xiaoxiao Yu,Yuesheng Zhu,Zhenzhai Cai,Lingmin Yu,Ying Lin,Hejie Yu,Zhanxiong Xue,Lingling Zhou

Frontiers in molecular neuroscience 11:287 PubMed30186110

2018

M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Li Wan,Liang Ren,Lulan Chen,Guoxiang Wang,Xu Liu,Benjamin H Wang,Yun Wang
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