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AB146635

MDL 72222, 5-HT3 receptor antagonist

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(4 Publications)

MW 314.21 g/mol, Purity >99%. Selective 5-HT3 receptor antagonist. Shows antiemetic effects in vivo. Suppresses voluntary ethanol consumption that is mediated by 5-HT3 receptor in rats.
1 Images
Chemical Structure - MDL 72222, 5-HT3 receptor antagonist (AB146635)
  • Chemical Structure

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Chemical Structure - MDL 72222, 5-HT3 receptor antagonist (AB146635)

2D chemical structure image of ab146635, MDL 72222, 5-HT3 receptor antagonist

Key facts

CAS number

40796-97-2

Purity

>99%

Form

Solid

form

Molecular weight

314.21 g/mol

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

Biological description

Selective 5-HT3 receptor antagonist. Shows antiemetic effects in vivo. Suppresses voluntary ethanol consumption that is mediated by 5-HT3 receptor in rats.

Isomeric smiles

CN3[C@@H]1CC[C@H]3C[C@H](C1)OC(=O)C2CC(CL)CC(CL)C2

IUPAC Name

3,5-Dichlorobenzoic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 16:297-310 PubMed16288851

2005

Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice.

Applications

Unspecified application

Species

Unspecified reactive species

T Kos,P Popik,M Pietraszek,D Schäfer,W Danysz,O Dravolina,E Blokhina,T Galankin,A Y Bespalov

American journal of clinical oncology 16:175-9 PubMed8452114

1993

Randomized comparison of the antiemetic efficacy of a serotonin type 3 receptor antagonist (MDL 72,222) with a high-dose metoclopramide regimen.

Applications

Unspecified application

Species

Unspecified reactive species

H D Homesley,W F Hahne,B McLees,K Heck,R J Barrett,S S Lentz,L Woodlief,J V Lovelace

Alcohol and alcoholism (Oxford, Oxfordshire) 26:107-10 PubMed1878073

1991

MDL 72222, a selective 5-HT3 receptor antagonist, suppresses voluntary ethanol consumption in alcohol-preferring rats.

Applications

Unspecified application

Species

Unspecified reactive species

F Fadda,B Garau,F Marchei,G Colombo,G L Gessa

Naunyn-Schmiedeberg's archives of pharmacology 326:36-44 PubMed6472484

1984

MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors.

Applications

Unspecified application

Species

Unspecified reactive species

J R Fozard
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