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AB120459

Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors

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(3 Publications)

MW 203.75 Da. Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 μM, 3.6 μM and 6.9 μM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice.
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Chemical Structure - Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors (AB120459)
  • Chemical Structure

Lab

Chemical Structure - Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors (AB120459)

2D chemical structure image of ab120459, Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors

Key facts

CAS number

826-39-1

Form

Solid

form

Molecular weight

203.75 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>2</sub><sub>2</sub>ClN

PubChem

13221

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 75 mM

Biochemical name

Mecamylamine hydrochloride

Biological description

Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 μM, 3.6 μM and 6.9 μM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice.

Canonical smiles

CC1(C2CCC(C2)C1(C)NC)C.Cl

InChi

InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H

InChiKey

PKVZBNCYEICAQP-UHFFFAOYSA-N

IUPAC Name

N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of psychopharmacology (Oxford, England) 30:676-87 PubMed27097732

2016

Acquisition and reinstatement of ethanol-induced conditioned place preference in rats: Effects of the cholinesterase inhibitors donepezil and rivastigmine.

Applications

Unspecified application

Species

Unspecified reactive species

Kinga Gawel,Krzysztof Labuz,Ewa Gibula-Bruzda,Malgorzata Jenda,Marta Marszalek-Grabska,Jerzy Silberring,Jolanta H Kotlinska

Cellular signalling 25:2634-45 PubMed24012499

2013

Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nagendra S Singh,Rajib K Paul,Anuradha Ramamoorthy,Marc C Torjman,Ruin Moaddel,Michel Bernier,Irving W Wainer

The Journal of physiology 591:203-17 PubMed23045343

2012

Direct and GABA-mediated indirect effects of nicotinic ACh receptor agonists on striatal neurones.

Applications

Unspecified application

Species

Unspecified reactive species

Ruixi Luo,Megan J Janssen,John G Partridge,Stefano Vicini
View all publications
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