MW 203.75 Da. Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 μM, 3.6 μM and 6.9 μM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice.
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- Journal of psychopharmacology (Oxford, England) 30:676-872016Acquisition and reinstatement of ethanol-induced conditioned place preference in rats: Effects of the cholinesterase inhibitors donepezil and rivastigmine.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKinga Gawel et. al.PubMed 27097732
- Cellular signalling 25:2634-452013Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNagendra S Singh et. al.PubMed 24012499
- The Journal of physiology 591:203-172012Direct and GABA-mediated indirect effects of nicotinic ACh receptor agonists on striatal neurones.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRuixi Luo,Megan J Janssen,John G Partridge,Stefano ViciniPubMed 23045343
Key facts
- CAS number
- 826-39-1
- Form
- Solid
- Molecular weight
- 203.75 Da
- Molecular formula
- C11H22ClN
- PubChem identifier
- 13221
- Nature
- Synthetic
Recommended products
MW 203.75 Da. Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 μM, 3.6 μM and 6.9 μM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice.
Key facts
- CAS number
- 826-39-1
- Form
- Solid
- Molecular weight
- 203.75 Da
- Molecular formula
- C11H22ClN
- PubChem identifier
- 13221
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
Soluble in DMSO to 75 mM.
- Biochemical name
- Mecamylamine hydrochloride
- Biological description
Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 μM, 3.6 μM and 6.9 μM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice.
- Canonical SMILES
- CC1(C2CCC(C2)C1(C)NC)C.Cl
- InChI
- InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
- InChIKey
- PKVZBNCYEICAQP-UHFFFAOYSA-N
- IUPAC name
- N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors (ab120459)
2D chemical structure image of ab120459, Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors
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