Medroxyprogesterone 17-acetate, Progesterone receptor agonist
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(2 Publications)
MW 386.5 Da, Purity >99%. Angiostatic steroid. Inhibit vascularization, collagenolysis, tumor growth and plasmin generation. Synthetic variant of progesterone, and a potent progesterone receptor agonist. Active in vitro and in vivo.
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17-beta-HSD 5, 17-beta-hydroxysteroid dehydrogenase type 5, 2-dihydrobenzene-1, 2-diol dehydrogenase, 20 alpha (3 alpha) hydroxysteroid dehydrogenase, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 2ALPHAHSD, 3 alpha hydroxysteroid dehydrogenase type II, 3 alpha hydroxysteroid dehydrogenase type III, 3-alpha-HSD type 2, 3-alpha-HSD type II, 3-alpha-HSD type II, brain, 3-alpha-HSD3, 3-alpha-hydroxysteroid dehydrogenase type 2, ABP, AIS, AK1C1_HUMAN, AK1C2_HUMAN, AK1C3_HUMAN, AKR1C pseudo, AKR1C1, AKR1C2, ANDR_HUMAN, AR, AR8, Akr1c18, Aldo-keto reductase family 1 member C1, Aldo-keto reductase family 1 member C2, Aldo-keto reductase family 1 member C3, Aldo-keto reductase family, 1 member 1, Aldosterone receptor, Androgen binding protein, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Atherosclerosis, susceptibility to, included, BABP, BXR, Bile acid binding protein, C9, Chlordecone reductase, Chlordecone reductase homolog, Chlordecone reductase homolog HAKRC, Chlordecone reductase homolog HAKRD, Chlordecone reductase homolog HAKRb, DD, DD-2, DD-3, DD/BABP, DD1, DD1/DD2, DDH, DDH 2, DDH1, DDX, DHTR, DKFZp686N23123, Dihydro testosterone receptor, Dihydrodiol dehydrogenase 1, Dihydrodiol dehydrogenase 1/2, Dihydrodiol dehydrogenase 2, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase X, Dihydrodiol dehydrogenase type I, Dihydrodiol dehydrogenase, type 1, Dihydrodiol dehydrogenase/bile acid-binding protein, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESR2_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta, Estrogen receptor beta 4, Estrogen resistance, included, FLJ53800, GCCR, GCRST, GCR_HUMAN, GR, Glucocorticoid receptor, Grl1, H37, HA1753, HAKRB, HAKRC, HAKRD, HAKRe, HBAB, HDL cholesterol, augmented response of, to hormone replacement, included, HSD17B5, HUMARA, HYSP1, Hepatic dihydrodiol dehydrogenase, High-affinity hepatic bile acid-binding protein, Indanol dehydrogenase, KD, KIAA0119, Kennedy disease (KD), MBAB, MCDR 2, MCR_HUMAN, MGC133092, MGC8954, MLR, MR, Mineralocorticoid receptor, Myocardial infarction, susceptibility to, included, NF-E2-related factor 2, NF2L2_HUMAN, NR1I2_HUMAN, NR3 C2, NR3A1, NR3A2, NR3C2 protein, NR3C3, NR3C4, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 2, Nuclear receptor subfamily 3 group C member 3, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), ONR 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000044759, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, PAR, PAR q, PGFS, PGR, PR, PRA, PRB, PRGR_HUMAN, PRR, Pregnane X receptor, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, Prostaglandin F synthase, Pseudo chlordecone reductase, RNESTROR, SBMA, SBP, SHBG_HUMAN, SMAX1, SRXY8, SXR, Sex hormone-binding globulin, Sex steroid-binding protein, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, TFM, TeBG, Testicular Feminization (TFM), Testis-specific androgen-binding protein, Testosterone 17-beta-dehydrogenase 5, Testosterone binding beta globulin, Testosterone-estradiol-binding globulin, Testosterone-estrogen-binding globulin, Trans-1, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type II 3 alpha hydroxysteroid dehydrogenase, Type II dihydrodiol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, Type IIb 3 alpha hydroxysteroid dehydrogenase, aldo-keto reductase C, androgen receptor splice variant 4b, dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase isoform DD1, erythroid derived 2, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, glucocorticoid nuclear receptor variant 1, hluPGFS, like 2, nr3c1, nuclear factor erythroid 2 like 2, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), pregnane X nuclear receptor variant 2
- Chemical Structure
Lab
Chemical Structure - Medroxyprogesterone 17-acetate, Progesterone receptor agonist (AB142633)
2D chemical structure image of ab142633, Medroxyprogesterone 17-acetate, Progesterone receptor agonist
Properties and storage information
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Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These receptors and proteins regulate gene expression influencing growth development and homeostasis. GR and MR bind glucocorticoids and mineralocorticoids modulating stress responses and salt-water balance. ER ERβ and PR mediate reproductive functions and cellular proliferation. AR targets androgen-responsive genes affecting male characteristics and fertility. PXR an orphan nuclear receptor detoxifies xenobiotics and is key in drug metabolism. Nrf2 a transcription factor governs antioxidant responses while SHBG regulates free steroid levels in circulation. These targets often form complexes with co-regulators for DNA binding and execution of cellular function.
Pathways
These targets are central to key signaling routes. GR and MR participate in the Hypothalamic-Pituitary-Adrenal axis and renin-angiotensin pathways connecting them to the body's stress and fluid balance regulation. ER and ERβ along with AR and PR integrate into estrogen and androgen pathways critical for sexual differentiation and reproductive health. These pathways involve interactions with other nuclear receptors and co-regulators that modulate their effects at cellular and systemic levels demonstrating their broad influence across physiological systems.
Publications (2)
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PLoS pathogens 21:e1013060 PubMed40198689
2025
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Cell death discovery 9:30 PubMed36693834
2023
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Unspecified reactive species
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