Melatonin, Endogenous hormone agonist at MT1 and MT2 receptors
Be the first to review this product! Submit a review
|
(1 Publication)
MW 232.28 Da, Purity >99%. Agonist at melatonin MT1 and MT2 receptors. Endogenous hormone important in the control of the circadian rhythm. Wide range of pathophysiological functions including antioxidative and immunomodulatory effects.
View Alternative Names
1,8-cineole 2-exo-monooxygenase, AHR_HUMAN, Ah receptor, Albendazole monooxygenase, Albendazole sulfoxidase, Aromatic hydrocarbon receptor, Aryl hydrocarbon hydroxylase, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, Atherosclerosis, susceptibility to, included, BXR, CP 12, CP1A2_HUMAN, CP1B, CP1B1_HUMAN, CP33, CP34, CP3A4_HUMAN, CYP1A2, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIA2, CYPIB1, CYPIIIA3, CYPIIIA4, Class E basic helix-loop-helix protein 76, Cytochrome P(3)450, Cytochrome P450 1A2, Cytochrome P450 1B1, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 1 polypeptide 2, Cytochrome P450 family 1 subfamily A polypeptide 2, Cytochrome P450 family 1 subfamily B polypeptide 1, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile), Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-P3, Cytochrome P450-PCN1, DHQV, DIA6, DKFZp686N23123, Dioxin inducable P3 450, EC 1.10.99.2, ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, FGQTL2, GLC3A, Glucocorticoid inducible P450, HDL cholesterol, augmented response of, to hormone replacement, included, HGNC:348, HLP, MEL-1A-R, MEL-1B-R, MGC126680, MGC94180, MR, MT 2 melatonin receptor, MT-1, MTNR 1A, MTR1A_HUMAN, MTR1B_HUMAN, Mel 1b, Mel 1b melatonin receptor, Mel1a melatonin receptor, Mel1a receptor, Mel1b receptor, MelR, Melatonin receptor 1A, Melatonin receptor MEL 1B, Melatonin receptor type 1A, Melatonin receptor type 1B, Microsomal monooxygenase, Mtnr 1b, Myocardial infarction, susceptibility to, included, NAD(P)H dehydrogenase quinone 2, NAD(P)H menadione oxidoreductase 1 dioxin inducible 2, NAD(P)H menadione oxidoreductase 2 dioxin inducible, NF 25, NMOR2, NQO2_HUMAN, NR1I2_HUMAN, NR3A1, NR3A2, NRH dehydrogenase, NRH dehydrogenase [quinone] 2, NRH:quinone oxidoreductase 2, Nifedipine oxidase, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, ONR 1, OTTHUMP00000015948, OTTHUMP00000015949, OTTHUMP00000015953, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, Ox 2, P(3)450, P3 450, P450 4, P450 III steroid inducible, P450 P3, P450 PCN1, P450 form 4, P450(PA), P450, family III, P4501B1, P450C3, PAR, PAR q, PRR, Pregnane X receptor, QR2, Quinine 3-monooxygenase, Quinone, Quinone reductase 2, RNESTROR, Ribosyldihydronicotinamide dehydrogenase, Ribosyldihydronicotinamide dehydrogenase [quinone], SXR, Steroid and xenobiotic receptor, Taurochenodeoxycholate 6-alpha-hydroxylase, Xenobiotic monooxygenase, bHLHe76, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, flavoprotein-linked monooxygenase, melatonin receptor 1B, pregnane X nuclear receptor variant 2
- Chemical Structure
Lab
Chemical Structure - Melatonin, Endogenous hormone agonist at MT1 and MT2 receptors (AB141052)
2D chemical structure image of ab141052, Melatonin, Endogenous hormone agonist at MT1 and MT2receptors
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins play significant roles in regulating body functions. Estrogen Receptor modulates gene transcription in response to estrogen and affects reproductive tissue growth. AhR participates in xenobiotic metabolism and detoxification processes. CYP1A2 and CYP3A4 are involved in the metabolism of drugs and endogenous compounds. PXR senses toxic substances and regulates the expression of enzymes like CYP3A4. MTNR1A and MTNR1B mediate the effects of melatonin an endogenous hormone on circadian rhythms and seasonal physiological functions. Together these receptors and enzymes form part of complexes that adjust biological responses to hormones and environmental signals.
Pathways
These proteins integrate into critical biological routes. Estrogen Receptor and AhR both interact with the hormone structure pathway influencing estrogen-associated transcription and xenobiotic response. Interestingly CYP3A4 linked via PXR is part of the drug metabolism pathway interacting with other proteins like CAR and RXR to regulate enzyme expression upon exposure to medications. AhR and CYP1A2 contribute to the aryl hydrocarbon receptor pathway which is essential for detoxifying harmful compounds and protection against oxidative stress and damage.
Product protocols
- Visit the General protocols
- Visit the Troubleshooting
Publications (1)
Recent publications for all applications. Explore the full list and refine your search
Journal of molecular cell biology 10:479-493 PubMed30060229
2018
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com