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AB141052

Melatonin, Endogenous hormone agonist at MT1 and MT2 receptors

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(1 Publication)

MW 232.28 Da, Purity >99%. Agonist at melatonin MT1 and MT2 receptors. Endogenous hormone important in the control of the circadian rhythm. Wide range of pathophysiological functions including antioxidative and immunomodulatory effects.

View Alternative Names

1,8-cineole 2-exo-monooxygenase, AHR_HUMAN, Ah receptor, Albendazole monooxygenase, Albendazole sulfoxidase, Aromatic hydrocarbon receptor, Aryl hydrocarbon hydroxylase, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, Atherosclerosis, susceptibility to, included, BXR, CP 12, CP1A2_HUMAN, CP1B, CP1B1_HUMAN, CP33, CP34, CP3A4_HUMAN, CYP1A2, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIA2, CYPIB1, CYPIIIA3, CYPIIIA4, Class E basic helix-loop-helix protein 76, Cytochrome P(3)450, Cytochrome P450 1A2, Cytochrome P450 1B1, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 1 polypeptide 2, Cytochrome P450 family 1 subfamily A polypeptide 2, Cytochrome P450 family 1 subfamily B polypeptide 1, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile), Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-P3, Cytochrome P450-PCN1, DHQV, DIA6, DKFZp686N23123, Dioxin inducable P3 450, EC 1.10.99.2, ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, FGQTL2, GLC3A, Glucocorticoid inducible P450, HDL cholesterol, augmented response of, to hormone replacement, included, HGNC:348, HLP, MEL-1A-R, MEL-1B-R, MGC126680, MGC94180, MR, MT 2 melatonin receptor, MT-1, MTNR 1A, MTR1A_HUMAN, MTR1B_HUMAN, Mel 1b, Mel 1b melatonin receptor, Mel1a melatonin receptor, Mel1a receptor, Mel1b receptor, MelR, Melatonin receptor 1A, Melatonin receptor MEL 1B, Melatonin receptor type 1A, Melatonin receptor type 1B, Microsomal monooxygenase, Mtnr 1b, Myocardial infarction, susceptibility to, included, NAD(P)H dehydrogenase quinone 2, NAD(P)H menadione oxidoreductase 1 dioxin inducible 2, NAD(P)H menadione oxidoreductase 2 dioxin inducible, NF 25, NMOR2, NQO2_HUMAN, NR1I2_HUMAN, NR3A1, NR3A2, NRH dehydrogenase, NRH dehydrogenase [quinone] 2, NRH:quinone oxidoreductase 2, Nifedipine oxidase, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, ONR 1, OTTHUMP00000015948, OTTHUMP00000015949, OTTHUMP00000015953, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, Ox 2, P(3)450, P3 450, P450 4, P450 III steroid inducible, P450 P3, P450 PCN1, P450 form 4, P450(PA), P450, family III, P4501B1, P450C3, PAR, PAR q, PRR, Pregnane X receptor, QR2, Quinine 3-monooxygenase, Quinone, Quinone reductase 2, RNESTROR, Ribosyldihydronicotinamide dehydrogenase, Ribosyldihydronicotinamide dehydrogenase [quinone], SXR, Steroid and xenobiotic receptor, Taurochenodeoxycholate 6-alpha-hydroxylase, Xenobiotic monooxygenase, bHLHe76, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, flavoprotein-linked monooxygenase, melatonin receptor 1B, pregnane X nuclear receptor variant 2

1 Images
Chemical Structure - Melatonin, Endogenous hormone agonist at MT1 and MT2 receptors (AB141052)
  • Chemical Structure

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Chemical Structure - Melatonin, Endogenous hormone agonist at MT1 and MT2 receptors (AB141052)

2D chemical structure image of ab141052, Melatonin, Endogenous hormone agonist at MT1 and MT2receptors

Key facts

CAS number

73-31-4

Purity

>99%

Form

Solid

form

Molecular weight

232.28 Da

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>6</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

896

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

Melatonin

Biological description

Agonist at melatonin MT1 and MT2 receptors. Endogenous hormone important in the control of the circadian rhythm. Wide range of pathophysiological functions including antioxidative and immunomodulatory effects.

Canonical smiles

CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC

InChi

InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)

InChiKey

DRLFMBDRBRZALE-UHFFFAOYSA-N

IUPAC Name

N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Receptor Aryl Hydrocarbon Receptor Cytochrome P450 enzymes PXR and Melatonin Receptors are important proteins involved in various physiological processes. Estrogen Receptor (ER) is a nuclear hormone receptor also known as ESR1 and its mass is approximately 66 kDa. ER is expressed in tissues like breast and uterus. Aryl Hydrocarbon Receptor (AhR) functions as a ligand-activated transcription factor and is found in a variety of tissues including liver and lungs. Cytochrome P450 1A2 (CYP1A2) and 3A4 (CYP3A4) are important for drug metabolism with CYP1A2 primarily in the liver and CYP3A4 in liver and intestine. PXR (Pregnane X Receptor) acts as a sensor for foreign substances and it is expressed mainly in the liver and intestine. Melatonin Receptors 1A (MTNR1A) and 1B (MTNR1B) are G protein-coupled receptors found in the central nervous system and retina.
Biological function summary

These proteins play significant roles in regulating body functions. Estrogen Receptor modulates gene transcription in response to estrogen and affects reproductive tissue growth. AhR participates in xenobiotic metabolism and detoxification processes. CYP1A2 and CYP3A4 are involved in the metabolism of drugs and endogenous compounds. PXR senses toxic substances and regulates the expression of enzymes like CYP3A4. MTNR1A and MTNR1B mediate the effects of melatonin an endogenous hormone on circadian rhythms and seasonal physiological functions. Together these receptors and enzymes form part of complexes that adjust biological responses to hormones and environmental signals.

Pathways

These proteins integrate into critical biological routes. Estrogen Receptor and AhR both interact with the hormone structure pathway influencing estrogen-associated transcription and xenobiotic response. Interestingly CYP3A4 linked via PXR is part of the drug metabolism pathway interacting with other proteins like CAR and RXR to regulate enzyme expression upon exposure to medications. AhR and CYP1A2 contribute to the aryl hydrocarbon receptor pathway which is essential for detoxifying harmful compounds and protection against oxidative stress and damage.

These targets connect to various health issues. Estrogen Receptor can influence breast cancer development as its signaling impacts cell proliferation and survival with implications for treatments targeting ER-positive tumors. CYP1A2 and CYP3A4 have associations with liver disorders due to their roles in metabolizing potentially hepatotoxic drugs. The Melatonin Receptors MTNR1A and MTNR1B relate to sleep disorders and are studied for their roles in sleep regulation and potential links to depression. Disorders in these pathways may also involve proteins such as PXR which can exacerbate metabolic diseases by altering drug and hormone metabolism.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular cell biology 10:479-493 PubMed30060229

2018

The genetic program of oocytes can be modified in vivo in the zebrafish ovary.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaotong Wu,Weimin Shen,Bingjie Zhang,Anming Meng
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