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AB146687

Memantine hydrochloride (mM/ml), NMDA antagonist

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(1 Publication)

MW 215.76 Da, Purity >98%. Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Used in the clinic to treat Alzheimer's disease. Cognitive enhancer and anxiolytic in vivo.

View Alternative Names

AMPA 1, AMPA-selective glutamate receptor 1, EPND, FESD, GLUH1, GRIA1_HUMAN, GRIN 2A, GluA1, GluN1, GluN2A, GluR-1, GluR-A, GluR-K1, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, HBGR1, LKS, MGC133252, MRD8, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N-methyl D-aspartate receptor subtype 2A, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA receptor 1, NMDA receptor subtype 2A, NMDAR, NMDE1_HUMAN, NMDZ1_HUMAN, NR1, NR2A, OTTHUMP00000160135, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000174531, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, glutamate receptor ionotropic, NMDA 1, hNR2A

Key facts

CAS number

41100-52-1

Purity

>98%

Form

Solid

form

Molecular weight

215.76 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>2</sub><sub>2</sub>ClN

PubChem

181458

Nature

Synthetic

Biochemical name

Memantine hydrochloride

Biological description

Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Used in the clinic to treat Alzheimer's disease. Cognitive enhancer and anxiolytic in vivo.

Canonical smiles

CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl

InChi

InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H

InChiKey

LDDHMLJTFXJGPI-UHFFFAOYSA-N

IUPAC Name

3,5-dimethyladamantan-1-amine;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NMDAR2A and NMDAR1 are subunits of the N-methyl-D-aspartate receptor (NMDAR) an important receptor type within the central nervous system. This receptor is a glutamate receptor and ion channel protein complex mainly found in neurons. The receptor has a mass of approximately 185 kDa. It requires binding of agonists like glutamate and glycine to function. NMDARs are located mainly at synapses where they play critical roles in synaptic transmission and plasticity.
Biological function summary

NMDARs are integral to learning and memory processes. These receptors are part of a larger heterotetrameric complex that contains two essential NR1 subunits and two region-specific NR2 subunits including NMDAR2A. NMDARs regulate calcium ion flow into the neuron when activated. This influx of calcium triggers signaling pathways involved in synaptic strength and plasticity. NMDARs modulate neural communication and have important roles in brain development and synaptic pruning.

Pathways

NMDA receptors participate in synaptic signaling pathways including the Long-term Potentiation (LTP) and Long-term Depression (LTD) pathways. These pathways are important for synaptic plasticity which underlies learning and memory. The receptor also interacts with proteins such as CaMKII and PSD-95 which help in receptor signaling and anchoring at the synaptic membrane. Their activity is modulated by other neurotransmitter systems such as GABAergic and dopaminergic systems indicating complex interactions in neural networks.

Dysfunction of NMDARs is linked to neurological conditions like Alzheimer's disease and schizophrenia. In Alzheimer's disease NMDAR function is altered affecting synaptic physiology and contributing to cognitive deficits. In schizophrenia dysregulation of NMDAR signaling is implicated in the disorder's pathophysiology. Schizophrenia-associated proteins like neuregulin 1 can modulate NMDAR function. Research continues to explore NMDARs as therapeutic targets in these disorders to develop better treatment strategies.
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:108933 PubMed38318354

2024

Cullin-RING E3 ubiquitin ligase 4 regulates neurite morphogenesis during neurodevelopment.

Applications

Unspecified application

Species

Unspecified reactive species

Tammy Shim,Jae Yeon Kim,WonCheol Kim,Yun-Il Lee,Bongki Cho,Cheil Moon
View all publications
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