Memantine hydrochloride, NMDA antagonist
Be the first to review this product! Submit a review
|
(1 Publication)
MW 215.76 Da, Purity >98%. Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Used in the clinic to treat Alzheimer's disease. Cognitive enhancer and anxiolytic in vivo.
View Alternative Names
AMPA 1, AMPA-selective glutamate receptor 1, EPND, FESD, GLUH1, GRIA1_HUMAN, GRIN 2A, GluA1, GluN1, GluN2A, GluR-1, GluR-A, GluR-K1, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, HBGR1, LKS, MGC133252, MRD8, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N-methyl D-aspartate receptor subtype 2A, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA receptor 1, NMDA receptor subtype 2A, NMDAR, NMDE1_HUMAN, NMDZ1_HUMAN, NR1, NR2A, OTTHUMP00000160135, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000174531, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, glutamate receptor ionotropic, NMDA 1, hNR2A
- FuncS
PubMed
Functional Studies - Memantine hydrochloride, NMDA antagonist (AB120249)
Averaged time courses of NMDA receptor-isolated synaptic field potentials in dorsal lateral bed nucleus of the stria terminalis following 60 minutes of memantine (5 or 30 μM; ab120249) in naive adult male C57BL/6J mice.
Image from Wills TA et al., Proc Natl Acad Sci U S A. 2012;109(5):E278-87. Fig 6(D).; doi: 10.1073/pnas.1113820109.
- Chemical Structure
Lab
Chemical Structure - Memantine hydrochloride, NMDA antagonist (AB120249)
2D chemical structure image of ab120249, Memantine hydrochloride, NMDA antagonist
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The GluR1 subunit is an essential component of the AMPA receptor complex which typically forms as a tetramer. This complex modulates synaptic strength and plasticity processes critical for learning and memory. The activity of AMPA receptors including those containing GluR1 is regulated by several auxiliary proteins and is essential for post-synaptic responses. The GluR1 subunit also interacts with other proteins such as TARPs which modulate its trafficking and channel properties.
Pathways
The GluR1-containing AMPA receptors participate significantly in the glutamatergic signaling pathway which is vital for fast excitatory synaptic transmission in the brain. This pathway also involves the NMDA receptors which work together with AMPA receptors to regulate synaptic plasticity and neuronal communication. Additionally the GluR1 interacts within the long-term potentiation (LTP) pathway contributing to the strengthening of synapses an essential mechanism underlying learning and memory.
Publications (1)
Recent publications for all applications. Explore the full list and refine your search
Proceedings of the National Academy of Sciences of 109:E278-87 PubMed22219357
2012
Applications
Unspecified application
Species
Unspecified reactive species
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com