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AB141272

Menadione, Phosphatase inhibitor

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MW 172.18 Da, Purity >99%. Vitamin K produg able to inhibit protein tyrosine phosphatases and induce DNA strand breaks. Able to prevent erlotinib (ab120881) induced cell-cycle arrest. Generates ROS°. Active in vivo.

View Alternative Names

3-dioxygenase, AHDC, AI838772, AIS, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH class 2, ALDH-E1, ALDH-E2, ALDHI, ALDM, ALHDII, ANDR_HUMAN, AO, AOFA_HUMAN, AOH1, AOX 1, AR, AR8, AW493413, Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase 2, Aldehyde dehydrogenase 1, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase 2 family, Aldehyde dehydrogenase 2 family (mitochondrial), Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase liver cytosolic, Aldehyde dehydrogenase mitochondrial, Aldehyde oxidase 1, Aldh, Amine oxidase (flavin containing), Amine oxidase (flavin containing) A, Amine oxidase (flavin containing) B, Amine oxidase [flavin-containing] A, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Antigen NY-CO-13, Atherosclerosis, susceptibility to, included, Azoreductase, BCC7, BLM_HUMAN, BS, Bloom syndrome, Bloom syndrome RecQ helicase like, Bloom syndrome protein, CMT1A, CMT1E, CPC12, CPC8, CPC9, CPCJ, CYP2C, CYP2C10, Cellular tumor antigen p53, Cytochrome b 5 reductase, DHQU, DHTR, DIA 4, DKFZp686N23123, DNA helicase, DNA helicase RecQ like type 2, DT-diaphorase, DTD, Diaphorase (NADH/NADPH), Diaphorase (NADH/NADPH) (cytochrome b 5 reductase), Diaphorase 4, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Dioxin inducible 1, EC 1.2.3.1, EC 1.4.3.4, ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, FLJ11090, FLJ92943, GAS-3, Growth Arrest Specific 3, Growth arrest-specific protein 3, HDL cholesterol, augmented response of, to hormone replacement, included, HMSNIA, HNPP, HUMARA, HYSP1, I23O1_HUMAN, IDO, IDO-1, IMD42, INDO, Indole 2 3 dioxygenase, Indoleamine 2,3-dioxygenase 1, Indoleamine pyrrole 2 3 dioxygenase, Indoleamine-pyrrole 2, KD, Kennedy disease (KD), LFS1, Liver mitochondrial ALDH, MAO, MAO-A, MAO-B, MGC104252, MGC112732, MGC126616, MGC129539, MGC131618, MGC131620, MGC1806, MGC20769, MGC2318, Menadione reductase, Mitochondrial aldehyde dehydrogenase 2, Monoamine oxidase, Monoamine oxidase A, Monoamine oxidase B, Monoamine oxidase type A, Monoamine oxidase type B, Mutant tumor protein 53, Myocardial infarction, susceptibility to, included, NAD(P)H dehydrogenase [quinone] 1, NAD(P)H dehydrogenase quinone 1, NAD(P)H menadione oxidoreductase 1 dioxin inducible, NAD(P)H quinone dehydrogenase 1, NAD(P)H: menadione oxidoreductase 1 dioxin inducible 1, NAD(P)H:Quinone acceptor oxidoreductase type 1, NAD(P)H:menadione oxidoreductase 1, NAD(P)H:quinone oxidoreductase 1, NAD(P)H:quinone oxireductase, NMOR 1, NMOR I, NQO1_HUMAN, NR1F3, NR3A1, NR3A2, NR3C4, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleus encoded mitochondrial aldehyde dehydrogenase 2, OTTHUMP00000017718, OTTHUMP00000017719, P450 PB 1, P450C2C, P450IIC19, P450IIC9, P53_HUMAN, PMP22_HUMAN, PUMB 1, Peripheral myelin protein 22, Phosphoprotein p53, Phylloquinone reductase, QR 1, Quinone reductase 1, RALDH 1, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RECQ 2, RECQ like, RECQL 2, RECQL 3, RNESTROR, RORG_HUMAN, RP24-311F12.2, RZR GAMMA, RZRG, RecQ protein-like 3, RecQ-like type 2, Retinal dehydrogenase 1, Retinaldehyde dehydrogenase 1, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SCAN1, SMAX1, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, TOR, TRP53, TYDP, TYDP1_HUMAN, Testicular Feminization (TFM), Tp53, Transformation related protein 53, Trembler, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, androgen receptor splice variant 4b, azaheterocycle hydroxylase, indolamine 2,3 dioxygenase, indoleamine 2 3 dioxygenase, p53 tumor suppressor, tumor antigen p55, type 2

1 Images
Chemical Structure - Menadione, Phosphatase inhibitor (AB141272)
  • Chemical Structure

Lab

Chemical Structure - Menadione, Phosphatase inhibitor (AB141272)

2D chemical structure image of ab141272, Menadione, Phosphatase inhibitor

Key facts

CAS number

58-27-5

Purity

>99%

Form

Solid

form

Molecular weight

172.18 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>8</sub>O<sub>2</sub>

PubChem

4055

Nature

Synthetic

Solubility

For more Solubility (Complete) data for MENADIONE (6 total), please visit the HSDB record page.

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

Biochemical name

Menadione

Biological description

Vitamin K produg able to inhibit protein tyrosine phosphatases and induce DNA strand breaks. Able to prevent erlotinib (ab120881) induced cell-cycle arrest. Generates ROS°. Active in vivo.

Canonical smiles

CC1=CC(=O)C2=CC=CC=C2C1=O

InChi

InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3

InChiKey

MJVAVZPDRWSRRC-UHFFFAOYSA-N

IUPAC Name

2-methylnaphthalene-1,4-dione

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store in the dark|The product can be stored for up to 12 months

Product protocols

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