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AB120847

Metformin hydrochloride, AMPK activator

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(11 Publications)

MW 165.62 Da, Purity >99%. AMPK activator. Antidiabetic and anticancer activity in vivo. Rapidly crosses the blood-brain barrier.

Also available in simple stock solutions (ab146725) - add 1 ml of water to get an exact, ready-to-use concentration.
1 Images
Chemical Structure - Metformin hydrochloride, AMPK activator (AB120847)
  • Chemical Structure

Lab

Chemical Structure - Metformin hydrochloride, AMPK activator (AB120847)

2D chemical structure image of ab120847, Metformin hydrochloride, AMPK activator

Key facts

CAS number

1115-70-4

Purity

>99%

Form

Solid

form

Molecular weight

165.62 Da

Molecular formula

C<sub>4</sub>H<sub>1</sub><sub>2</sub>ClN<sub>5</sub>

PubChem

14219

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 50 mM. Sonication and heating in a water bath to approximately 45 °C are required to produce a clear solution in DMSO.

Biochemical name

Metformin hydrochloride

Biological description

AMPK activator. Antidiabetic and anticancer activity in vivo. Rapidly crosses the blood-brain barrier.

Also available in simple stock solutions (ab146725) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical smiles

CN(C)C(=N)N=C(N)N.Cl

InChi

InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChiKey

OETHQSJEHLVLGH-UHFFFAOYSA-N

IUPAC Name

3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

  • 5
  • 105
Biochemicals

AB120358

AICAR (Acadesine/AICA riboside), AMPK activator

Functional Studies - AICAR (Acadesine/AICA riboside), AMPK activator (AB120358)

  • 0
  • 0
Biochemicals

AB120726

Resveratrol, Antioxidant polyphenol

Immunocytochemistry/ Immunofluorescence - Resveratrol, Antioxidant polyphenol (AB120726)

  • 0
  • 0
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Physiological reports 11: PubMed38010200

2023

Influence of metabolic stress and metformin on synaptic protein profile in SH-SY5Y-derived neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Alex J T Yang,Ahmad Mohammad,Michael S Finch,Evangelia Tsiani,Gaynor Spencer,Aleksandar Necakov,Rebecca E K MacPherson

Stem cell research & therapy 13:157 PubMed35410372

2022

Evaluation of photoreceptor-directed fibroblasts derived from retinitis pigmentosa patients with defects in the EYS gene: a possible cost-effective cellular model for mechanism-oriented drug.

Applications

Unspecified application

Species

Unspecified reactive species

Dilip Rai,Masaki Iwanami,Yoriko Takahashi,Yukari Komuta,Noriyuki Aoi,Akihiro Umezawa,Yuko Seko

Scientific reports 11:8743 PubMed33888740

2021

The antiviral effect of metformin on zika and dengue virus infection.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos Noe Farfan-Morales,Carlos Daniel Cordero-Rivera,Juan Fidel Osuna-Ramos,Irma Eloisa Monroy-Muñoz,Luis Adrián De Jesús-González,José Esteban Muñoz-Medina,Arianna M Hurtado-Monzón,José Manuel Reyes-Ruiz,Rosa María Del Ángel

Aging 12:23233-23250 PubMed33221742

2020

NEAT1 regulates microtubule stabilization via FZD3/GSK3β/P-tau pathway in SH-SY5Y cells and APP/PS1 mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yiwan Zhao,Ziqiang Wang,Yunhao Mao,Bing Li,Yuanchang Zhu,Shikuan Zhang,Songmao Wang,Yuyang Jiang,Naihan Xu,Yizhen Xie,Weidong Xie,Yaou Zhang

Autophagy 17:2494-2510 PubMed33030392

2020

Metformin rescues muscle function in BAG3 myofibrillar myopathy models.

Applications

Unspecified application

Species

Unspecified reactive species

Avnika A Ruparelia,Emily A McKaige,Caitlin Williams,Keith E Schulze,Margit Fuchs,Viola Oorschot,Emmanuelle Lacene,Mirella Meregalli,Clara Lee,Rita J Serrano,Emily C Baxter,Keyne Monro,Yvan Torrente,Georg Ramm,Tanya Stojkovic,Josée N Lavoie,Robert J Bryson-Richardson

Cells 9: PubMed31936169

2020

Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanchao Gong,Caihong Wang,Yi Jiang,Shaosen Zhang,Shi Feng,Yan Fu,Yongzhang Luo

The Journal of biological chemistry 295:1754-1766 PubMed31901078

2020

14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation.

Applications

Unspecified application

Species

Unspecified reactive species

Anirban Kundu,Sandeep Shelar,Arindam P Ghosh,Mary Ballestas,Richard Kirkman,Hyeyoung Nam,Garrett J Brinkley,Suman Karki,James A Mobley,Sejong Bae,Sooryanarayana Varambally,Sunil Sudarshan

Nature 565:505-510 PubMed30651639

2019

Human blood vessel organoids as a model of diabetic vasculopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Reiner A Wimmer,Alexandra Leopoldi,Martin Aichinger,Nikolaus Wick,Brigitte Hantusch,Maria Novatchkova,Jasmin Taubenschmid,Monika Hämmerle,Christopher Esk,Joshua A Bagley,Dominik Lindenhofer,Guibin Chen,Manfred Boehm,Chukwuma A Agu,Fengtang Yang,Beiyuan Fu,Johannes Zuber,Juergen A Knoblich,Dontscho Kerjaschki,Josef M Penninger

Experimental biology and medicine (Maywood, N.J.) 242:1490-1498 PubMed28766983

2017

LKB1-AMPK modulates nutrient-induced changes in the mode of division of intestinal epithelial crypt cells in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine Blackmore,Weinan Zhou,Megan J Dailey

PLoS pathogens 13:e1006257 PubMed28384260

2017

DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target.

Applications

Unspecified application

Species

Unspecified reactive species

Rubén Soto-Acosta,Patricia Bautista-Carbajal,Margot Cervantes-Salazar,Antonio H Angel-Ambrocio,Rosa M Del Angel
View all publications
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