MW 370.5 Da, Purity >98%. Selective, active site directed, irreversible cPLA 2 and iPLA2 inhibitor. Potent FAAH inhibitor (IC50 = 2.5 nM). I nhibits A23187 (ab120287, ab142245, ab142244)-induced arachidonic acid release from platelets (IC50 = 600 nM). Potent, irreversible anandamide amidase inhibitor. Prolongs and intensifies aerobic exercise-induced antinociceptive effects *in vivo*.
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- Frontiers in cell and developmental biology 10:9669502022Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria Mangini,Rosa D'Angelo,Caterina Vinciguerra,Christine Payré,Gérard Lambeau,Barbara Balestrieri,Julia F Charles,Stefania MariggiòPubMed 36105351
Key facts
- Purity
- > 98%
- Form
- Liquid
- Molecular weight
- 370.5 Da
- Molecular formula
- C21H36FO2P
- PubChem identifier
- 10429254
- Nature
- Synthetic
Alternative names
Anandamide amidohydrolase, Anandamide amidohydrolase 1, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, CNR1_HUMAN, CPLA 2, Calcium dependent phospholipid binding protein, Cannabinoid receptor 1, Central cannabinoid receptor, Cytosolic phospholipase A2, Cytosolic phospholipase A2 group IVA, EC 3.1.1.23, FA2H, FAAH, FAAH1_HUMAN, Fatty acid 2-hydroxylase, Fatty acid alpha-hydroxylase, Fatty acid amide hydrolase, Fatty-acid amide hydrolase 1, HU-K5, Intracellular platelet activating factor acetylhydrolase alpha 2 subunit, Lysophospholipase, Lysophospholipase homolog, Lysophospholipase-like, MAGL, MGC102823, MGC126350, MGC138146, MGL, MGLL_HUMAN, Monoacylglycerol lipase, Monoglyceride lipase, OTTHUMP00000016838, OTTHUMP00000214579, Oleamide hydrolase, Oleamide hydrolase 1, PA1B2_HUMAN, PA24A_HUMAN, PAF AH beta subunit, PAF acetylhydrolase 30 kDa subunit, PAF-AH 30 kDa subunit, PAF-AH subunit beta, PAFAH1B2 protein, PAFAHB, PLA2G4, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2, Phospholipase A2 group 4 A, Phospholipase A2 group IVA, Phospholipase A2, group IVA (cytosolic, calcium-dependent), Platelet activating factor acetylhydrolase 1b catalytic subunit 2, Platelet activating factor acetylhydrolase IB beta subunit, Platelet activating factor acetylhydrolase isoform Ib beta subunit, Platelet activating factor acetylhydrolase isoform Ib subunit 2, Platelet-activating factor acetylhydrolase IB subunit beta, cPLA2-alpha, pla2g4a
Recommended products
MW 370.5 Da, Purity >98%. Selective, active site directed, irreversible cPLA 2 and iPLA2 inhibitor. Potent FAAH inhibitor (IC50 = 2.5 nM). I nhibits A23187 (ab120287, ab142245, ab142244)-induced arachidonic acid release from platelets (IC50 = 600 nM). Potent, irreversible anandamide amidase inhibitor. Prolongs and intensifies aerobic exercise-induced antinociceptive effects *in vivo*.
Key facts
- Purity
- > 98%
- Form
- Liquid
- Molecular weight
- 370.5 Da
- Molecular formula
- C21H36FO2P
- PubChem identifier
- 10429254
- Nature
- Synthetic
- Biochemical name
- Methoxy arachidonyl fluorophosphonate
- Biological description
Selective, active site directed, irreversible cPLA 2 and iPLA2 inhibitor. Potent FAAH inhibitor (IC50 = 2.5 nM). I nhibits A23187 (ab120287, ab142245, ab142244)-induced arachidonic acid release from platelets (IC50 = 600 nM). Potent, irreversible anandamide amidase inhibitor. Prolongs and intensifies aerobic exercise-induced antinociceptive effects *in vivo*.
- Canonical SMILES
- CCCCCC=CCC=CCC=CCC=CCCCCP(=O)(OC)F
- Isomeric SMILES
- CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(=O)(OC)F
- InChI
- InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
- InChIKey
- KWKZCGMJGHHOKJ-ZKWNWVNESA-N
- IUPAC name
- (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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Chemical Structure - Methyl Arachidonyl Fluorophosphonate, irreversible cPLA2 and iPLA2 inhibitor (ab141763)
2D chemical structure image of ab141763, Methyl Arachidonyl Fluorophosphonate,irreversible cPLA2 and iPLA2 inhibitor
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