MW 874.9 Da, Purity >98%. Potent, selective antagonist at α7-containing nicotinic receptors.
Also available in simple stock solutions (ab146684) - add 1 ml of water to get an exact, ready-to-use concentration.
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- European journal of pain (London, England) 28:297-3092023Effect of spirocyclopiperazinium salt compound LXM-15 on spinal nerve injury in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTian Yu Wang,Ying Ying Liang,Qin Liu,Ding Wang,Qi Sun,Run Tao Li,Hua Yang,Yi Min Jiang,Jia YePubMed 37668323
- Neuroscience letters 731:1351182020PNU282987 alleviates Aβ-induced anxiety and depressive-like behaviors through upregulation of α7nAChR by ERK-serotonin receptors pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKe-Wei Chang et. al.PubMed 32502508
- Behavioural brain research 313:214-2182016The combination of memantine and galantamine improves cognition in rats: The synergistic role of the α7 nicotinic acetylcholine and NMDA receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAgnieszka Nikiforuk,Agnieszka Potasiewicz,Tomasz Kos,Piotr PopikPubMed 27435422
- Cell research 26:728-422016Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing Zhang et. al.PubMed 27103432
- Acta cirurgica brasileira 30:736-422015Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSaeed Sadigh-Eteghad,Javad Mahmoudi,Shirin Babri,Mahnaz TalebiPubMed 26647792
- Journal of neurophysiology 112:1549-582014Functional expression of α7-nicotinic acetylcholine receptors by muscle afferent neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJames C Baxter,Renuka Ramachandra,Dustin R Mayne,Keith S ElmsliePubMed 24966300
- PloS one 7:e329512012Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596.Applications:Unspecified applicationReactive species:Unspecified reactive speciesVictor V UteshevPubMed 22479351
- Neuropharmacology 61:1379-882011Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain α4 and β2 subunits.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKaren A Bell et. al.PubMed 21878344
Key facts
- CAS number
- 112825-05-5
- Purity
- > 98%
- Form
- Solid
- Source
- Delphinium
- Molecular weight
- 874.9 Da
- Molecular formula
- C43H58N2O17
- PubChem identifier
- 90479749
- Nature
- Native
Recommended products
MW 874.9 Da, Purity >98%. Potent, selective antagonist at α7-containing nicotinic receptors.
Also available in simple stock solutions (ab146684) - add 1 ml of water to get an exact, ready-to-use concentration.
Key facts
- CAS number
- 112825-05-5
- Purity
- > 98%
- Form
- Solid
- Source
- Delphinium
- Molecular weight
- 874.9 Da
- Molecular formula
- C43H58N2O17
- PubChem identifier
- 90479749
- Nature
- Native
- Solubility
Soluble in water to 10 mM.
- Biochemical name
- [(1R,2R,3R,4S,5R,6S,8R,9R,10R,13S,16S,18S)-11-ethyl-8,9-dihydroxy-4,6,16,18-tetramethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl]methyl 2-[(3S)-3-methyl-2,5-dioxopyrrolidin-1-yl]benzoate;2-hydroxypropane-1,2,3-tricarboxylic acid
- Biological description
Potent, selective antagonist at α7-containing nicotinic receptors.
Also available in simple stock solutions (ab146684) - add 1 ml of water to get an exact, ready-to-use concentration.- Canonical SMILES
- CCN1CC2(CCC(C34C2C(C(C31)(C5(CC(C6CC4C5C6OC)OC)O)O)OC)OC)COC(=O)C7=CC=CC=C7N8C(=O)CC(C8=O)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
- Isomeric SMILES
- CCN1C[C@@]2(CC[C@@H]([C@@]34[C@@H]1[C@@]([C@H](C23)OC)([C@]5(C[C@@H]([C@H]6C[C@@H]4[C@@H]5[C@H]6OC)OC)O)O)OC)COC(=O)C7=CC=CC=C7N8C(=O)C[C@@H](C8=O)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
- InChI
- InChI=1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t19-,21+,22+,24-,25-,27+,28-,29?,30-,33+,34-,35+,36+,37-;/m0./s1
- InChIKey
- INBLZNJHDLEWPS-IRPACCRLSA-N
- IUPAC name
- [(1R,2R,3R,4S,5R,6S,8R,9R,10R,13S,16S,18S)-11-ethyl-8,9-dihydroxy-4,6,16,18-tetramethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl]methyl 2-[(3S)-3-methyl-2,5-dioxopyrrolidin-1-yl]benzoate;2-hydroxypropane-1,2,3-tricarboxylic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - Methyllycaconitine citrate (MLA), alpha7 Nicotinic receptor antagonist (ab120072)
2D chemical structure image of ab120072, Methyllycaconitine citrate (MLA), alpha7 Nicotinic receptor antagonist
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