Mevastatin, HMG-CoA reductase inhibitor

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(4 Publications)

MW 390.5 Da, Purity >98%. Potent HMG-CoA reductase inhibitor. Proapoptotic, able to arrest cells in G₁ by down-regulation of CDK4, CDK6 and cyclin D1 and up-regulation of p21 and p27.

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3 hydroxy 3 methylglutaryl CoA reductase, 3 hydroxymethylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3H3M, ABC member 16, MDR/TAP subfamily, ABC16, ABCB1, ABCBB_HUMAN, AI838772, AIS, ANDR_HUMAN, AR, AR8, ASRT2, ATP binding cassette sub family B (MDR/TAP) member 11, ATP-binding cassette sub-family B member 11, AW493413, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), BDPLT5, BRIC2, Bile salt export pump, Bsep, CD 87, CD87 antigen, Cytosolic NADP-isocitrate dehydrogenase, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), EC 3.4.21.73, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Epididymis luminal protein 216, Epididymis secretory protein Li 26, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, FLJ11090, G protein coupled receptor 154, G protein coupled receptor PGR14, G protein coupled receptor for asthma susceptibility, GPR 154, GPRA, HEL-216, HEL-S-26, HMDH_HUMAN, HMG CoAR, HMG-CoA reductase, HUMARA, HYSP1, Hydroxymethylglutaryl CoA reductase, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, KD, Kennedy disease (KD), LDLCQ3, MGC103269, MGC104252, MGC112732, MO 3, MVTR, Monocyte activation antigen Mo3, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, NPSR, NR3B1, NR3C4, Neuropeptide S receptor, Neuropeptide S receptor 1, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Oxalosuccinate decarboxylase, PFIC 2, PGR 14, PGY4, PICD, PLAU, PLAUR, PLG, PLMN_HUMAN, Plasmin, Plasmin heavy chain A, Plasmin light chain B, Plasminogen, Plasminogen activator receptor urokinase, Plasminogen activator urokinase receptor, QPD, RP24-311F12.2, SBMA, SCAN1, SMAX1, Sister of P glycoprotein, Spgp, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid hormone receptor ERR1, TFM, TYDP, TYDP1_HUMAN, Testicular Feminization (TFM), Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, U-plasminogen activator, UPA receptor, UPAM, UPAR_HUMAN, URK, URKR, Urinary plasminogen activator, Urinary plasminogen activator receptor, Urokinase plasminogen activator, Urokinase plasminogen activator receptor, Urokinase plasminogen activator surface receptor, Urokinase type plasminogen activator, VRR 1, Vasopressin receptor related receptor 1, androgen receptor splice variant 4b, estrogen receptor related receptor alpha, hERR1, nps receptor, progressive familial intrahepatic cholestasis 2, u plasminogen activator receptor, u-PA, u-plasminogen activator receptor form 2, urokinase-type plasminogen activator (uPA) receptor