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MW 475.6 Da, Purity >98%. MG-132, proteasome inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.


Images

Chemical Structure - MG-132, proteasome inhibitor (AB141003), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - MG-132, proteasome inhibitor (AB141003), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - MG-132, proteasome inhibitor (AB141003), expandable thumbnail
  • Immunoprecipitation - MG-132, proteasome inhibitor (AB141003), expandable thumbnail
  • Flow Cytometry (Intracellular) - MG-132, proteasome inhibitor (AB141003), expandable thumbnail

Publications

Key facts

CAS number
133407-82-6
Purity
> 98%
Form
Solid
Molecular weight
475.6 Da
Molecular formula
C26H41N3O5
PubChem identifier
462382
Nature
Synthetic

Target data

Alternative names

DKFZp459C139, EC 3.4.25.1, HC7 I, LMPX, MB1, MGC104214, MGC118075, MGC134464, Macropain epsilon chain, Macropain subunit C7-I, Multicatalytic endopeptidase complex epsilon chain, Multicatalytic endopeptidase complex subunit C7 1, Multicatalytic endopeptidase complex subunit C7-I, PSB2_HUMAN, PSB5_HUMAN, PSMB2, PSMB5, PSX large multifunctional protease X, Proteasome (prosome, macropain) subunit beta type 2, Proteasome (prosome, macropain) subunit, beta type, 5, Proteasome beta 2 subunit, Proteasome beta 5 subunit, Proteasome catalytic subunit 3, Proteasome chain 6, Proteasome component C7-I, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X, Proteasome subunit beta type-2, Proteasome subunit beta type-5, Proteasome subunit, beta-5

Recommended products

MW 475.6 Da, Purity >98%. MG-132, proteasome inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.

Key facts

Purity
> 98%
PubChem identifier
462382
Solubility

Soluble in DMSO to 100 mM but unstable for prolonged periods.

Soluble in ethanol to 100 mM.

Biochemical name
Z-Leu-leu-leu-al
Canonical SMILES
CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
InChI
InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
InChIKey
TZYWCYJVHRLUCT-VABKMULXSA-N
IUPAC name
benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store under desiccating conditions

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Proteasome subunit beta type 2 or PSMB2 also known as PSMB5/MB1 is an essential component of the proteasome complex with a molecular weight of approximately 26 kDa. This subunit participates in the assembly of the 20S core protease complex important for protein degradation functions within cells. PSMB2 is ubiquitously expressed in various tissues reflecting its broad role in cellular homeostasis. It contributes to the active sites of the proteasome facilitating the breakdown of ubiquitinated proteins.

Biological function summary

The PSMB2 and PSMB5 subunits play a role in regulated protein degradation as part of the ATP-dependent 26S proteasome complex. This complex orchestrates the degradation of unneeded or damaged proteins by proteolysis a chemical reaction that breaks peptide bonds. PSMB2 aids in maintaining protein quality control and cellular regulation by processing peptides into smaller fragments for further degradation or presentation by MHC class I molecules. Its activity is essential for regulating numerous cellular processes including cell cycle control signal transduction and immune responses.

Pathways

The PSMB2 protein participates in key pathways such as the ubiquitin-proteasome pathway and the NF-κB signaling pathway. Its involvement in these pathways highlights its role in protein homeostasis and immune regulation within cells. The ubiquitin-proteasome pathway relies on several other proteins including ubiquitin itself and E3 ligases which tag proteins for degradation. PSMB2 collaborates with similar subunits to execute regulated protein breakdown ensuring proper cell function and adaptive responses to cellular stress.

Associated diseases and disorders

PSMB2's dysregulation associates with conditions such as multiple myeloma and certain neurodegenerative disorders like Alzheimer's disease. In multiple myeloma alterations in PSMB2 expression contribute to the enhanced survival of malignant cells which may involve interactions with other proteasome inhibitors like MG132. This connection highlights potential therapeutic avenues targeting proteasome components to ameliorate disease symptoms and progression. In Alzheimer's disease PSMB2 may intertwine with amyloid precursor protein processing influencing pathogenic protein aggregation and neuronal damage.

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