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AB145047

MI 2, MALT1 inhibitor

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(1 Publication)

MW 455.73 g/mol, Purity >98%. Cell-permeable, irreversible MALT1 inhibitor (IC50 = 5.8 μM). Suppresses protease function, decreases NF-κB activity and inhibits cell proliferation. Antitumor agent. Active in vitro, in vivo and ex vivo.
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Chemical Structure - MI 2, MALT1 inhibitor (AB145047)
  • Chemical Structure

Lab

Chemical Structure - MI 2, MALT1 inhibitor (AB145047)

2D chemical structure image of ab145047, MI 2, MALT1 inhibitor

Key facts

CAS number

1047953-91-2

Purity

>98%

Form

Solid

form

Molecular weight

455.73 g/mol

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>7</sub>Cl<sub>3</sub>N<sub>4</sub>O<sub>3</sub>

Nature

Synthetic

Solubility

Soluble in ethanol to 50 mM

Soluble in DMSO to 100 mM

Biological description

Cell-permeable, irreversible MALT1 inhibitor (IC50 = 5.8 μM). Suppresses protease function, decreases NF-κB activity and inhibits cell proliferation. Antitumor agent. Active in vitro, in vivo and ex vivo.

Canonical smiles

CLCC(=O)NC1CCC(CC1)N3NC(NC3C2CCC(CL)C(CL)C2)OCCOC

InChi

InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)

InChiKey

TWJGQZBSEMDPQP-UHFFFAOYSA-N

IUPAC Name

2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenyl]acetamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 9:456 PubMed38097554

2023

Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Binjie Yan,Darrell Belke,Yu Gui,Yong-Xiang Chen,Zhi-Sheng Jiang,Xi-Long Zheng
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