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AB120755

Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor

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MW 282.81 g/mol, Purity >99%. Serotonin and norepinephrine reuptake inhibitor. IC50 values are 100, 203 and >100000 nM for NA, 5-HT and DA, respectively. Centrally active following oral administration. Exhibits antidepressant and antifibromyalgia activity in vivo.
2 Images
Immunocytochemistry/ Immunofluorescence - Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor (AB120755)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor (AB120755)

ab113202 staining NET1 in PC-12 cells treated with milnacipran hydrochloride (ab120755), by ICC/IF. Decrease of NET1 expression correlates with increased concentration of milnacipran hydrochloride, as described in literature.
The NGF treated cells were incubated at 37°C for 6 hour in media containing different concentrations of ab120755 (milnacipran hydrochloride ) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab113202 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor (AB120755)
  • Chemical Structure

Lab

Chemical Structure - Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor (AB120755)

2D chemical structure image of ab120755, Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor

Key facts

CAS number

101152-94-7

Purity

>99%

Form

Solid

form

Molecular weight

282.81 g/mol

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>2</sub>N<sub>2</sub>O.HCl

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biological description

Serotonin and norepinephrine reuptake inhibitor. IC50 values are 100, 203 and >100000 nM for NA, 5-HT and DA, respectively. Centrally active following oral administration. Exhibits antidepressant and antifibromyalgia activity in vivo.

IUPAC Name

(1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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