MW 282.81 g/mol, Purity >99%. Serotonin and norepinephrine reuptake inhibitor. IC50 values are 100, 203 and >100000 nM for NA, 5-HT and DA, respectively. Centrally active following oral administration. Exhibits antidepressant and antifibromyalgia activity in vivo.
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Key facts
- CAS number
- 101152-94-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 282.81 g/mol
- Molecular formula
- C15H22N2O.HCl
- Nature
- Synthetic
Recommended products
MW 282.81 g/mol, Purity >99%. Serotonin and norepinephrine reuptake inhibitor. IC50 values are 100, 203 and >100000 nM for NA, 5-HT and DA, respectively. Centrally active following oral administration. Exhibits antidepressant and antifibromyalgia activity in vivo.
Key facts
- CAS number
- 101152-94-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 282.81 g/mol
- Molecular formula
- C15H22N2O.HCl
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
Soluble in DMSO to 100 mM.
- Biological description
Serotonin and norepinephrine reuptake inhibitor. IC50 values are 100, 203 and >100000 nM for NA, 5-HT and DA, respectively. Centrally active following oral administration. Exhibits antidepressant and antifibromyalgia activity in vivo.
- IUPAC name
- (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor (ab120755)
2D chemical structure image of ab120755, Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor
Immunocytochemistry/ Immunofluorescence - Milnacipran hydrochloride, Serotonin and norepinephrine reuptake inhibitor (ab120755)
Anti-NET1 antibody ab113202 staining NET1 in PC-12 cells treated with milnacipran hydrochloride (ab120755), by ICC/IF. Decrease of NET1 expression correlates with increased concentration of milnacipran hydrochloride, as described in literature.
The NGF treated cells were incubated at 37°C for 6 hour in media containing different concentrations of ab120755 (milnacipran hydrochloride ) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-NET1 antibody ab113202 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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